# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4344938 | B | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in catalase expression at 10 uM using compound pre-activated with hydrogen peroxide for 8 hrs prior to NRVM treatment and measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
2. | ALA4344939 | P | Stability of compound in HBS buffer at 1 mM at pH 7.3 and 37 degree C by HPLC or LC-MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4344940 | P | Drug degradation in HBS buffer assessed as half life at 1 mM at pH 7.3 and 37 degree C by HPLC or LC-MS analysis | 1 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA4344941 | A | Prodrug conversion in HBS buffer assessed as peroxide-mediated formation of N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide at pH 7.4 measured within 2 hrs in presence of 20 molar equivalent peroxide by HPLC analysis | 1 | assay format | Scientific Literature | |||
5. | ALA4344942 | A | Prodrug conversion in HBS buffer assessed as peroxide-mediated formation of N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide at pH 7.4 and 37 degree C measured within 2 hrs in presence of 0.1 molar equivalent peroxide by HPLC analysis | 1 | assay format | Scientific Literature | |||
6. | ALA4344943 | A | Prodrug conversion in HBS buffer assessed as peroxide-mediated formation of N-[2-[(4-hydroxyphenyl)methoxy]-5-methylphenyl]-3-phenylpropanamide at pH 7.4 and 37 degree C incubated for 10 mins in presence of 10 molar equivalent hydrogen peroxide by LC-MS analysis | 1 | assay format | Scientific Literature | |||
7. | ALA4344948 | A | Substrate activity at recombinant CYP1A2 (unknown origin) assessed as [4-[[4-methyl-2-(3-phenylpropanoylamino)phenoxy]methyl]phenyl]boronic acid formation incubated for 24 hrs in presence of NADP+ by LC-MS analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
8. | ALA4344949 | B | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in GRP78 expression at 10 uM using compound pre-activated with hydrogen peroxide for 8 hrs prior to NRVM treatment and measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
9. | ALA4344952 | F | Cytoprotection against hydrogen peroxide-induced toxicity in NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability at 10 uM pretreated for 24 hrs followed by hydrogen peroxide challenge measured after 8 hrs by MTT assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
10. | ALA4344953 | B | Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs by LDH assay | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
11. | ALA4344954 | B | Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs under normoxia condition by calcein-AM green dye based fluorescence microscopy | Rattus norvegicus | 2 | single protein format | Scientific Literature |