# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4433811 | B | Transactivation of GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase reporter gene assay | Homo sapiens | 14 | ALA4433217 | cell-based format | Scientific Literature | |
2. | ALA4433812 | B | Transactivation of GAL4-tagged human PPARgamma LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase reporter gene assay | Homo sapiens | 14 | ALA4433217 | cell-based format | Scientific Literature | |
3. | ALA4433813 | B | Transactivation of GAL4-tagged human PPARdelta LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase reporter gene assay | Homo sapiens | 14 | ALA4433217 | cell-based format | Scientific Literature | |
4. | ALA4433814 | B | Transactivation of GAL4-tagged human PPARalpha LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase reporter gene assay relative to clofibric acid | Homo sapiens | 13 | ALA4433217 | cell-based format | Scientific Literature | |
5. | ALA4433815 | B | Transactivation of GAL4-tagged human PPARgamma LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase reporter gene assay relative to rosiglitazone | Homo sapiens | 13 | ALA4433217 | cell-based format | Scientific Literature | |
6. | ALA4433816 | B | Transactivation of GAL4-tagged human PPARdelta LBD expressed in human HepG2 cells at 100 nM to 100 uM incubated for 20 to 22 hrs by luciferase reporter gene assay relative to L165,041 | Homo sapiens | 13 | ALA4433217 | cell-based format | Scientific Literature | |
7. | ALA4433818 | B | Agonist activity at PPARalpha in human HepG2 cells assessed as increase in CPT1A RNA expression at 100 uM incubated for 48 hrs by qRT-PCR analysis relative to control | Homo sapiens | 1 | ALA4433217 | cell-based format | Scientific Literature | |
8. | ALA4433819 | B | Agonist activity at PPARdelta in human HepG2 cells assessed as increase in PDK4 RNA expression at 100 uM incubated for 48 hrs by qRT-PCR analysis relative to control | Homo sapiens | 1 | ALA4433217 | cell-based format | Scientific Literature | |
9. | ALA4433820 | B | Agonist activity at PPARgamma in human HepG2 cells assessed as increase in GLUT1 RNA expression at 100 uM incubated for 48 hrs by qRT-PCR analysis relative to control | Homo sapiens | 1 | ALA4433217 | cell-based format | Scientific Literature | |
10. | ALA4433821 | F | Ex vivo antiinflammatory activity in Sprague-Dawley rat liver assessed as inhibition of LPS-induced PGE2 production at 0.1 to 10 uM incubated for 4 hrs followed by LPS addition by radioimmunoassay | Rattus norvegicus | 1 | ALA4433217 | tissue-based format | Scientific Literature | |
11. | ALA4433822 | F | Ex vivo antiinflammatory activity in Sprague-Dawley rat cortex assessed as inhibition of LPS-induced PGE2 production at 0.1 to 10 uM incubated for 4 hrs followed by LPS addition by radioimmunoassay | Rattus norvegicus | 1 | ALA4433217 | tissue-based format | Scientific Literature |