# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385680 | A | Negative chronotropic activity in guinea pig spontaneously beating right atrium assessed as decrease in atrial rate | Cavia porcellus | 16 | ALA4385592 | tissue-based format | Scientific Literature | |
2. | ALA4385682 | A | Selectivity ratio of EC50 for negative chronotropic activity in guinea pig spontaneously beating right atrium to EC50 for negative inotropic activity in guinea pig left atrium | Cavia porcellus | 10 | ALA4385592 | tissue-based format | Scientific Literature | |
3. | ALA4385684 | B | Inhibition of voltage-dependent L-type calcium channel in human U373MG cells assessed as protection against oxygen glucose deprivation/reperfusion-induced injury by measuring recovery of cell viability at 1 uM administered at onset of reperfusion period measured after 16 hrs by alamar blue assay relative to control | Homo sapiens | 36 | ALA4385592 | cell-based format | Scientific Literature | |
4. | ALA4385685 | B | Inhibition of voltage-dependent L-type calcium channel in human U373MG cells assessed as protection against oxygen glucose deprivation/reperfusion-induced injury by measuring recovery of cell viability at 20 uM administered at onset of reperfusion period measured after 16 hrs by alamar blue assay relative to control | Homo sapiens | 36 | ALA4385592 | cell-based format | Scientific Literature | |
5. | ALA4385686 | B | Inhibition of voltage-dependent L-type calcium channel in human SH-SY5Y cells assessed as protection against glutamate-induced excitotoxicity by measuring recovery of cell viability at 1 uM measured after 24 hrs by alamar blue-based fluorescence method relative to control | Homo sapiens | 36 | ALA4385592 | cell-based format | Scientific Literature | |
6. | ALA4385687 | B | Inhibition of voltage-dependent L-type calcium channel in human SH-SY5Y cells assessed as protection against glutamate-induced excitotoxicity by measuring recovery of cell viability at 20 uM measured after 24 hrs by alamar blue-based fluorescence method relative to control | Homo sapiens | 36 | ALA4385592 | cell-based format | Scientific Literature | |
7. | ALA4385688 | B | Inhibition of voltage-dependent L-type calcium channel in Wistar rat brain slices assessed as protection against oxygen glucose deprivation/reperfusion-induced injury by measuring recovery of LDH release at 20 uM administered at onset of reperfusion period measured after 90 mins by spectrophotometric assay relative to control | Rattus norvegicus | 20 | ALA4385592 | tissue-based format | Scientific Literature | |
8. | ALA4385689 | B | Inhibition of voltage-dependent L-type calcium channel in Wistar rat brain slices assessed as protection against oxygen glucose deprivation/reperfusion-induced injury by measuring recovery of edema formation at 20 uM administered at onset of reperfusion period measured after 90 mins relative to control | Rattus norvegicus | 20 | ALA4385592 | tissue-based format | Scientific Literature | |
9. | ALA4385693 | A | Negative inotropic activity in guinea pig left atrium assessed as decrease in developed tension at 5 x 10'-6 M relative to control | Cavia porcellus | 6 | ALA4385592 | tissue-based format | Scientific Literature | |
10. | ALA4385697 | A | Negative inotropic activity in guinea pig left atrium assessed as decrease in developed tension at 0.001 to 100 uM relative to control | Cavia porcellus | 20 | ALA4385592 | tissue-based format | Scientific Literature | |
11. | ALA4385702 | A | Negative chronotropic activity in guinea pig spontaneously beating right atrium assessed as decrease in atrial rate at 10'-5 M relative to control | Cavia porcellus | 12 | ALA4385592 | tissue-based format | Scientific Literature | |
12. | ALA4385713 | A | Inhibition of calcium-induced contraction in K+-depolarized guinea pig aortic strips at 10'-4 M relative to control | Cavia porcellus | 16 | ALA4385592 | tissue-based format | Scientific Literature |