# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4358949 | B | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex incubated for 45 mins by liquid scintillation spectrometry | Homo sapiens | 41 | ALA4354864 | tissue-based format | Scientific Literature | |
2. | ALA4358950 | B | Displacement of [3H]RX821002 from alpha2-AR in human brain frontal cortex incubated for 30 mins by liquid scintillation spectrometry | Homo sapiens | 38 | ALA4354864 | tissue-based format | Scientific Literature | |
3. | ALA4358951 | B | Selectivity index, ratio of pKi for alpha2-AR human brain frontal cortex to pKi for I2IR in human brain frontal cortex | Homo sapiens | 17 | ALA4354864 | assay format | Scientific Literature | |
4. | ALA4358952 | B | Displacement of [3H]clonidine from I1IR in human brain frontal cortex in presence of adrenaline incubated for 45 mins by liquid scintillation spectrometry | Homo sapiens | 16 | ALA4354864 | tissue-based format | Scientific Literature | |
5. | ALA4358953 | B | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex assessed as binding affinity at high affinity site incubated for 45 mins by liquid scintillation spectrometry | Homo sapiens | 10 | ALA4354864 | tissue-based format | Scientific Literature | |
6. | ALA4358954 | B | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex assessed as binding affinity at low affinity site incubated for 45 mins by liquid scintillation spectrometry | Homo sapiens | 9 | ALA4354864 | tissue-based format | Scientific Literature | |
7. | ALA4358955 | B | Displacement of [3H]2-BFI from I2IR in human brain frontal cortex assessed as binding affinity at high affinity site incubated for 45 mins by liquid scintillation spectrometry relative to control | Homo sapiens | 9 | ALA4354864 | tissue-based format | Scientific Literature | |
8. | ALA4358956 | B | Displacement of [3H]2-BFI from I2IR in Sprague-Dawley rat brain cortex incubated for 45 mins by liquid scintillation spectrometry | Rattus norvegicus | 2 | ALA4354864 | assay format | Scientific Literature | |
9. | ALA4358957 | B | Displacement of [3H]2-BFI from I2IR in Swiss mouse brain cortex incubated for 45 mins by liquid scintillation spectrometry | Mus musculus | 2 | ALA4354864 | assay format | Scientific Literature | |
10. | ALA4358962 | A | Effective permeability of compound by PAMPA-BBB assay | 1 | ALA4354864 | assay format | Scientific Literature | ||
11. | ALA4358963 | A | Cytotoxicity against human HeLa cells assessed as effect on cell morphology at 100 uM incubated for 3 to 5 days by microscopic analysis | Homo sapiens | 1 | ALA4354864 | cell-based format | Scientific Literature | |
12. | ALA4358964 | A | Cytotoxicity against monkey Vero cells assessed as effect on cell morphology at 100 uM incubated for 3 to 5 days by microscopic analysis | Chlorocebus sabaeus | 1 | ALA4354864 | cell-based format | Scientific Literature | |
13. | ALA4358965 | A | Cytotoxicity against dog MDCK cells assessed as effect on cell morphology at 100 uM incubated for 3 to 5 days by microscopic analysis | Canis lupus familiaris | 1 | ALA4354864 | cell-based format | Scientific Literature | |
14. | ALA4358966 | A | Cytotoxicity against human MT4 cells assessed as effect on cell morphology at 100 uM incubated for 3 to 5 days by microscopic analysis | Homo sapiens | 1 | ALA4354864 | cell-based format | Scientific Literature | |
15. | ALA4358967 | A | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 100 uM incubated for 3 to 5 days by colorimetric analysis | Homo sapiens | 1 | ALA4354864 | cell-based format | Scientific Literature | |
16. | ALA4358968 | A | Cytotoxicity against monkey Vero cells assessed as reduction in cell viability at 100 uM incubated for 3 to 5 days by colorimetric analysis | Chlorocebus sabaeus | 1 | ALA4354864 | cell-based format | Scientific Literature | |
17. | ALA4358969 | A | Cytotoxicity against dog MDCK cells assessed as reduction in cell viability at 100 uM incubated for 3 to 5 days by colorimetric analysis | Canis lupus familiaris | 1 | ALA4354864 | cell-based format | Scientific Literature | |
18. | ALA4358970 | A | Cytotoxicity against human MT4 cells assessed as reduction in cell viability at 100 uM incubated for 3 to 5 days by colorimetric analysis | Homo sapiens | 1 | ALA4354864 | cell-based format | Scientific Literature | |
19. | ALA4358971 | A | Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 3 to 5 days by colorimetric analysis | Homo sapiens | 1 | ALA4354864 | cell-based format | Scientific Literature | |
20. | ALA4358972 | P | Solubility of compound in 99% PBS buffer incubated for 2 hrs by nephelometry | 1 | ALA4354864 | small-molecule physicochemical format | Scientific Literature |