# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385407 | Functional | Antileishmanial activity against promastigote stage of Leishmania donovani MHOM/IN/00/DEVI after 72 hrs by MTT assay | Leishmania donovani | 30 | ALA4382286 | organism-based format | Scientific Literature | |
2. | ALA4385408 | ADME | Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay | Homo sapiens | 34 | ALA4382286 | cell-based format | Scientific Literature | |
3. | ALA4385409 | Physicochemical | Solubility of the compound in RPMI medium at 4 to 6 uM | 11 | ALA4382286 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4385410 | Toxicity | Selectivity index, ratio of CC50 for human HepG2 cells to IC50 for promastigote stage of Leishmania donovani MHOM/IN/00/DEVI | 26 | ALA4382286 | assay format | Scientific Literature | ||
5. | ALA4385411 | Functional | Antileishmanial activity against intracellular amastigote stage of Leishmania donovani infected in human THP1 cells after 120 hrs by giemsa staining based microscopic analysis | Leishmania donovani | 8 | ALA4382286 | organism-based format | Scientific Literature | |
6. | ALA4385412 | Functional | Antileishmanial activity against Leishmania infantum axenic amastigotes after 48 hrs by steady-glo luciferase reporter gene assay | Leishmania infantum | 8 | ALA4382286 | organism-based format | Scientific Literature | |
7. | ALA4385413 | Functional | Antileishmanial activity against promastigote stage of Leishmania major MHOM/IL/81/Friedlin after 72 hrs by MTT assay | Leishmania major | 3 | ALA4382286 | organism-based format | Scientific Literature | |
8. | ALA4385414 | Functional | Antileishmanial activity against intracellular amastigote stage of Leishmania major infected in human THP1 cells after 120 hrs by giemsa staining based microscopic analysis | Leishmania major | 3 | ALA4382286 | organism-based format | Scientific Literature | |
9. | ALA4385417 | Functional | Antiprotozoal activity against Trichomonas vaginalis TVR87 measured after 48 hrs by trypan blue assay | Trichomonas vaginalis | 3 | ALA4382286 | organism-based format | Scientific Literature | |
10. | ALA4385419 | Functional | Antitrypanosomal activity against trypomastigote stage of Trypanosoma brucei brucei AnTat 1.9 assessed as decrease in parasite viability after 69 hrs by Alamar Blue assay | Trypanosoma brucei brucei | 8 | ALA4382286 | organism-based format | Scientific Literature | |
11. | ALA4385420 | Functional | Antitrypanosomal activity against Trypanosoma cruzi MHOM/BR/78/Silvio cloneX10/7A epimastigotes measured after 4 days by resazurin dye based fluorescence assay | Trypanosoma cruzi | 5 | ALA4382286 | organism-based format | Scientific Literature | |
12. | ALA4385421 | ADME | Cytotoxicity against human THP1 cells after 72 hrs by MTT assay | Homo sapiens | 5 | ALA4382286 | cell-based format | Scientific Literature | |
13. | ALA4385422 | Physicochemical | Solubility of the compound in RPMI medium at >62.5 uM | 2 | ALA4382286 | small-molecule physicochemical format | Scientific Literature |