# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4338980 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC after 1 min in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
2. | ALA4338981 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC after 2 mins in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
3. | ALA4338982 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC after 5 mins in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
4. | ALA4338983 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC after 10 mins in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
5. | ALA4338984 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC after 20 mins in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
6. | ALA4338985 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC after 30 mins in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
7. | ALA4338987 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC measured immediately in presence of 150 units/ml of CES1 enzyme by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
8. | ALA4338988 | A | Prodrug conversion assessed as CES1 (unknown origin) mediated aztreonam and beta-lactam ring-opened prodrug intermediate release in 2.5% acetonitrile in 0.05M citrate buffer at 0.5 mg/ml at pH 4.7 at 37degC in presence of CES1 at lower concentration by HPLC analysis | Homo sapiens | 3 | single protein format | Scientific Literature | ||
9. | ALA4338989 | P | Stability of the compound in 2.5% acetonitrile in 0.05M citrate buffer assessed as aztreonam and beta-lactam ring-opened prodrug intermediate release at 0.5 mg/ml at pH 4.7 at 37degC by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature |