# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4415456 | A | AUC (0 to t) in ICR mouse plasma at 50 mg/kg, po administered via gavage measured after 0.25 to 24 hrs by UPLC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
2. | ALA4415457 | A | Tmax in ICR mouse plasma at 50 mg/kg, po administered via gavage measured after 0.25 to 24 hrs by UPLC/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
3. | ALA4415459 | A | Cmax in dog plasma at 3 mg/kg, po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
4. | ALA4415460 | B | Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in Escherichia coli BL21 cells assessed as residual binding level at 1 uM measured after 1 hr by quantitative PCR based BROMOscan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
5. | ALA4415461 | B | Binding affinity to human partial length BRWD1 (A1310 to E1430 residues) expressed in Escherichia coli BL21 cells assessed as residual binding level at 1 uM measured after 1 hr by quantitative PCR based BROMOscan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4415462 | B | Binding affinity to human partial length SMARCA4 (A1448 to S1575 residues) expressed in Escherichia coli BL21 cells assessed as residual binding level at 1 uM measured after 1 hr by quantitative PCR based BROMOscan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4415463 | B | Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in Escherichia coli BL21 cells assessed as residual binding level at 1 uM measured after 1 hr by quantitative PCR based BROMOscan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4415464 | B | Binding affinity to human partial length PB1 bromodomain 2 (S178 to E291 residues) expressed in Escherichia coli BL21 cells assessed as residual binding level at 1 uM measured after 1 hr by quantitative PCR based BROMOscan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4415465 | A | Tmax in ICR mouse at 10 mg/kg, po administered via gavage measured after 0.25 to 24 hrs by UPLC/MS analysis | Mus musculus | 5 | organism-based format | Scientific Literature | ||
10. | ALA4415466 | A | Time-dependent inhibition of CYP2C19 in human liver microsomes at 10 uM using mephenytoin as substrate preincubated up to 30 mins followed by NADPH generating system addition and measured after 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
11. | ALA4415467 | A | Time-dependent inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated up to 30 mins followed by NADPH generating system addition and measured after 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
12. | ALA4415468 | A | Time-dependent inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated up to 30 mins followed by NADPH generating system addition and measured after 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
13. | ALA4415469 | A | Time-dependent inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated up to 30 mins followed by NADPH generating system addition and measured after 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
14. | ALA4415470 | A | Time-dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using midazolam or testosterone as substrate preincubated up to 30 mins followed by NADPH generating system addition and measured after 10 mins | Homo sapiens | 6 | microsome format | Scientific Literature | ||
15. | ALA4415471 | A | Reversible inhibition of CYP2C19 in human liver microsomes at 10 uM using mephenytoin as substrate preincubated for 5 mins followed by NADPH generating system addition and measured after 20 mins relative to control | Homo sapiens | 5 | microsome format | Scientific Literature | ||
16. | ALA4415472 | A | Reversible inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate preincubated for 5 mins followed by NADPH generating system addition and measured after 20 mins relative to control | Homo sapiens | 5 | microsome format | Scientific Literature | ||
17. | ALA4415473 | A | Reversible inhibition of CYP2C9 in human liver microsomes at 10 uM using diclofenac as substrate preincubated for 5 mins followed by NADPH generating system addition and measured after 20 mins relative to control | Homo sapiens | 5 | microsome format | Scientific Literature | ||
18. | ALA4415474 | A | Reversible inhibition of CYP2D6 in human liver microsomes at 10 uM using dextromethorphan as substrate preincubated for 5 mins followed by NADPH generating system addition and measured after 20 mins relative to control | Homo sapiens | 5 | microsome format | Scientific Literature | ||
19. | ALA4415475 | A | Half life in mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 5 to 30 mins by LC/MS/MS analysis | Mus musculus | 4 | microsome format | Scientific Literature | ||
20. | ALA4415476 | A | Intrinsic clearance in mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 5 to 30 mins by LC/MS/MS analysis | Mus musculus | 4 | microsome format | Scientific Literature |