| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4360242 | B | Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketoglutarate substrate and NADPH addition after 45 mins by diaphorase and resazurin dye based assay | Homo sapiens | 70 | single protein format | Scientific Literature | ||
| 2. | ALA4360243 | A | Metabolic stability in human liver microsomes assessed as compound remaining after 30 mins | Homo sapiens | 66 | microsome format | Scientific Literature | ||
| 3. | ALA4360244 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining after 30 mins | Mus musculus | 60 | microsome format | Scientific Literature | ||
| 4. | ALA4360245 | P | Kinetic solubility of the compound | 66 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4360246 | B | Inhibition of human Myc-DDK-tagged IDH1 R132C mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketoglutarate substrate and NADPH addition after 45 mins by diaphorase and resazurin dye based assay | Homo sapiens | 31 | single protein format | Scientific Literature | ||
| 6. | ALA4360247 | B | Inhibition of wild-type IDH1 (unknown origin) by NADPH fluorescence based assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA4360248 | B | Inhibition of IDH1 R132H mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 8. | ALA4360249 | B | Inhibition of IDH1 R132C mutant in human HCT116 cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 9. | ALA4360250 | B | Inhibition of human Myc-DDK-tagged IDH1 R132H mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4360251 | B | Inhibition of human Myc-DDK-tagged IDH1 R132C mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4360253 | A | Free drug concentration in plasma of po dosed BALB/c nude mouse xenografted with human HCT116 harboring R132H mutant administered at 12 hrs intervals and measured after 4 to 24 hrs post last dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4360254 | F | In vivo inhibition of IDH1 R132H mutant in human HCT116 cells xenografted in po dosed BALB/c nude mouse assessed as reduction in plasma 2-HG level administered at 12 hrs intervals | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4360259 | A | Metabolic stability in rat liver microsomes assessed as compound remaining after 30 mins | Rattus norvegicus | 7 | microsome format | Scientific Literature | ||
| 14. | ALA4360260 | B | Inhibition of human Myc-DDK-tagged IDH1 R132G mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4360261 | B | Inhibition of human Myc-DDK-tagged IDH1 R132L mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4360262 | B | Inhibition of human Myc-DDK-tagged IDH1 R132S mutant expressed in human U87MG cells assessed as reduction in 2-HG levels after 24 hrs by RapidFire high-throughput mass spectrometry assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4360263 | A | Permeability of the compound by PAMPA | 2 | assay format | Scientific Literature | |||
| 18. | ALA4360264 | A | Apparent permeability of the compound across apical side to basolateral side in human Caco2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4360265 | A | Apparent permeability of the compound across basolateral side to apical side in human Caco2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4360266 | A | Efflux ratio of apparent permeability from basolateral side to apical side over apical side to basolateral side in human Caco2 cells | Homo sapiens | 2 | cell-based format | Scientific Literature |
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