| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4323086 | B | Binding affinity to recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) assessed as melting temperature at 20 uM by Sypro orange dye based differential scanning fluorimetry | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 2. | ALA4323087 | B | Binding affinity to recombinant human His-tagged SPIN4 (36 to 249 residues) expressed in Escherichia coli BL21 (DE3) assessed as melting temperature at 20 uM by Sypro orange dye based differential scanning fluorimetry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 3. | ALA4323088 | B | Binding affinity to recombinant human His-tagged SPIN3 (27 to 258 residues) expressed in Escherichia coli BL21 (DE3) assessed as melting temperature at 20 uM by Sypro orange dye based differential scanning fluorimetry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA4323089 | B | Binding affinity to recombinant human His-tagged SPIN2B (45 to 258 residues) expressed in Escherichia coli BL21 (DE3) assessed as melting temperature at 20 uM by Sypro orange dye based differential scanning fluorimetry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA4323090 | B | Binding affinity to recombinant human His-tagged SPIN4 (36 to 249 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 6. | ALA4323091 | B | Binding affinity to recombinant human His-tagged SPIN3 (27 to 258 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA4323092 | B | Binding affinity to recombinant human His-tagged SPIN2B (45 to 258 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 8. | ALA4323093 | B | Binding affinity to recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 9. | ALA4323094 | B | Selectivity index, ratio of IC50 for PRDM9 (unknown origin) to IC50 for recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4323095 | A | Apparent permeability from apical side to basolateral side in human Caco2 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4323096 | B | Selectivity index, ratio of IC50 for PRMT4 (unknown origin) to IC50 for recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 12. | ALA4323097 | B | Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins followed by peptide addition and measured after 1 hr by Alphascreen method | Homo sapiens | 18 | assay format | Scientific Literature | ||
| 13. | ALA4323099 | B | Inhibition of C-terminal Halotag-histone 3.3 tagged SPIN1 (unknown origin) transfected in human U2OS cells cotransfected with nano-luciferase at 1 uM using NanoBRET Nano-Glo substrate as substrate incubated for 24 hrs by NanoBRET assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA4323100 | A | Cytotoxicity against human U2OS cells assessed as reduction in cell viability at >3 uM incubated for 2 days by propidium iodide staining based assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 15. | ALA4323101 | B | Binding affinity to human His-tagged SPIN1 (21 to 262 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant preincubated for 5 mins followed by compound addition by octet BLI assay | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 16. | ALA4323102 | B | Binding affinity to recombinant human His-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | Homo sapiens | 7 | assay format | Scientific Literature | ||
| 17. | ALA4323103 | B | Selectivity index, ratio of IC50 for SETD2 (unknown origin) to IC50 for recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 18. | ALA4323104 | B | Selectivity index, ratio of IC50 for PRMT7 (unknown origin) to IC50 for recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4323105 | B | Selectivity index, ratio of IC50 for SUV39H1 (unknown origin) to IC50 for recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4323106 | B | Selectivity index, ratio of IC50 for PRMT6 (unknown origin) to IC50 for recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia coli BL21 (DE3) | Homo sapiens | 1 | assay format | Scientific Literature |
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