| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4400175 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced IL-6 production at 10 uM preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by sandwich ELISA relative to control | Mus musculus | 4 | ALA4396951 | cell-based format | Scientific Literature | |
| 2. | ALA4400176 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha production at 10 uM preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by sandwich ELISA relative to control | Mus musculus | 4 | ALA4396951 | cell-based format | Scientific Literature | |
| 3. | ALA4400179 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced IL-6 production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by sandwich ELISA | Mus musculus | 4 | ALA4396951 | cell-based format | Scientific Literature | |
| 4. | ALA4400180 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation and measured after 24 hrs by sandwich ELISA | Mus musculus | 4 | ALA4396951 | cell-based format | Scientific Literature | |
| 5. | ALA4400181 | A | Cytotoxicity against human BEAS2B cells up to 50 uM | Homo sapiens | 1 | ALA4396951 | cell-based format | Scientific Literature | |
| 6. | ALA4400182 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha mRNA expression preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4396951 | cell-based format | Scientific Literature | |
| 7. | ALA4400183 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced IL-6 mRNA expression preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4396951 | cell-based format | Scientific Literature | |
| 8. | ALA4400184 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced VCAM1 mRNA expression preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4396951 | cell-based format | Scientific Literature | |
| 9. | ALA4400185 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced ICAM1 mRNA expression preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4396951 | cell-based format | Scientific Literature | |
| 10. | ALA4400186 | F | Antiinflammatory activity in C57BL/6 mouse primary peritoneal macrophages assessed as inhibition of LPS-induced MCP1 mRNA expression preincubated for 30 mins followed by LPS stimulation and measured after 6 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4396951 | cell-based format | Scientific Literature | |
| 11. | ALA4400187 | B | Binding affinity to recombinant human MD2 by SPR analysis | Homo sapiens | 3 | ALA4396951 | single protein format | Scientific Literature | |
| 12. | ALA4400188 | B | Inhibition of TLR4/MD2 interaction in LPS-induced C57BL/6 mouse primary peritoneal macrophages followed by LPS-stimulation and measured after 10 mins by co-immunoprecipitation method | Mus musculus | 1 | ALA4396951 | protein complex format | Scientific Literature | |
| 13. | ALA4400189 | B | Inhibition of MAPK in C57BL/6 mouse primary peritoneal macrophages assessed as reduction in JNK phosphorylation at 10 uM preincubated for 30 mins followed by LPS-stimulation measured after 20 mins by Western blot analysis | Mus musculus | 1 | ALA4396951 | assay format | Scientific Literature | |
| 14. | ALA4400190 | B | Inhibition of MAPK in C57BL/6 mouse primary peritoneal macrophages assessed as reduction in ERK phosphorylation at 10 uM preincubated for 30 mins followed by LPS-stimulation measured after 20 mins by Western blot analysis | Mus musculus | 1 | ALA4396951 | assay format | Scientific Literature | |
| 15. | ALA4400191 | B | Inhibition of MAPK in C57BL/6 mouse primary peritoneal macrophages assessed as reduction in P38 phosphorylation at 10 uM preincubated for 30 mins followed by LPS-stimulation measured after 20 mins by Western blot analysis | Mus musculus | 1 | ALA4396951 | assay format | Scientific Literature | |
| 16. | ALA4400192 | F | Antiinflammatory activity in LPS-induced C57BL/6 mouse model of acute lung injury assessed as reduction in total cells in BALF at 10 to 20 mg/kg/day, po for 3 days followed by LPS-stimulation measured after 6 hrs by cell counting based method | Mus musculus | 1 | ALA4396951 | organism-based format | Scientific Literature | |
| 17. | ALA4400193 | F | Antiinflammatory activity in LPS-induced C57BL/6 mouse model of acute lung injury assessed as reduction in total protein levels in BALF at 10 to 20 mg/kg/day, po for 3 days followed by LPS-stimulation measured after 6 hrs | Mus musculus | 1 | ALA4396951 | organism-based format | Scientific Literature | |
| 18. | ALA4400194 | F | Antiinflammatory activity in LPS-induced C57BL/6 mouse model of acute lung edema assessed as decrease in lung wet/dry ratio at 20 mg/kg/day, po for 3 days followed by LPS-stimulation measured after 6 hrs | Mus musculus | 1 | ALA4396951 | organism-based format | Scientific Literature | |
| 19. | ALA4400195 | F | Antiinflammatory activity in oral dosed LPS-induced C57BL/6 mouse model of acute lung injury assessed as reduction in TNFalpha levels in BALF for 3 days followed by LPS-stimulation measured after 6 hrs | Mus musculus | 1 | ALA4396951 | organism-based format | Scientific Literature | |
| 20. | ALA4400196 | F | Antiinflammatory activity in oral dosed LPS-induced C57BL/6 mouse model of acute lung injury assessed as reduction in IL-6 levels in BALF for 3 days followed by LPS-stimulation measured after 6 hrs | Mus musculus | 1 | ALA4396951 | organism-based format | Scientific Literature |
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