| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4326358 | Functional | Agonist activity at GPR88 (unknown origin) expressed in PPLS-HA-GPR88 CHO cells assessed as effect on forskolin-induced cAMP accumulation after 30 mins by Eu-cAMP tracer-based TR-FRET assay | Homo sapiens | 13 | ALA4325833 | cell-based format | Scientific Literature | |
| 2. | ALA4326359 | ADME | Permeability across apical to basolateral side in MDCK-MDR1 cells at 10 uM after 1 hr by LC-MS analysis | Canis lupus familiaris | 4 | ALA4325833 | cell-based format | Scientific Literature | |
| 3. | ALA4326360 | Physicochemical | Thermodynamic solubility of the compound at pH 7.4 after 24 hrs by LC-MS/MS analysis | 4 | ALA4325833 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA4326361 | Functional | Agonist activity at GPR88 in wild type mouse striatal membranes assessed as increase in [35S]-GTPgammaS binding after 1 hr by liquid scintillation counting | Mus musculus | 2 | ALA4325833 | cell membrane format | Scientific Literature | |
| 5. | ALA4326362 | Functional | Increase in [35S]-GTPgammaS binding in GPR88 knocked out mouse striatal membranes at 100 uM after 1 hr by liquid scintillation counting | Mus musculus | 1 | ALA4325833 | cell membrane format | Scientific Literature | |
| 6. | ALA4326364 | ADME | Displacement of [3H]-dihydrotetrabenazine from VMAT in human platelet cell membranes at 10 uM after 60 mins by scintillation counting relative to control | Homo sapiens | 1 | ALA4325833 | cell-based format | Scientific Literature | |
| 7. | ALA4326365 | ADME | Binding affinity to human full length KOR assessed as reduction in radioligand binding at 10 uM after 60 mins by scintillation counting relative to control | Homo sapiens | 1 | ALA4325833 | single protein format | Scientific Literature | |
| 8. | ALA4326366 | ADME | Inhibition of human SERT expressed in HEK293 cells assessed as reduction in SERT-mediated substrate uptake after 30 mins by fluorescence-based assay | Homo sapiens | 1 | ALA4325833 | cell-based format | Scientific Literature | |
| 9. | ALA4326367 | ADME | Displacement of [3H]-Paroxetine from recombinant human full length SERT at 10 uM after 60 mins by scintillation counting relative to control | Homo sapiens | 1 | ALA4325833 | single protein format | Scientific Literature | |
| 10. | ALA4326368 | ADME | Displacement of [3H]-Paroxetine from recombinant human full length SERT after 60 mins by scintillation counting | Homo sapiens | 1 | ALA4325833 | single protein format | Scientific Literature | |
| 11. | ALA4326369 | ADME | Displacement of [3H]-dihydrotetrabenazine from VMAT in human platelet cell membranes after 60 mins by scintillation counting | Homo sapiens | 1 | ALA4325833 | cell-based format | Scientific Literature | |
| 12. | ALA4326370 | ADME | Binding affinity to human full length KOR after 60 mins by radioligand-based scintillation counting | Homo sapiens | 1 | ALA4325833 | single protein format | Scientific Literature | |
| 13. | ALA4326371 | ADME | Cmax in Long-Evans rat plasma at 10 mg/kg, ip after 15 mins by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 14. | ALA4326372 | ADME | Half life in Long-Evans rat plasma at 10 mg/kg, ip by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 15. | ALA4326373 | ADME | AUC (0 to infinity) in Long-Evans rat plasma at 10 mg/kg, ip by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 16. | ALA4326374 | ADME | Cmax in Long-Evans rat brain at 10 mg/kg, ip after 60 mins by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 17. | ALA4326375 | ADME | Half life in Long-Evans rat brain at 10 mg/kg, ip by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 18. | ALA4326376 | ADME | AUC (0 to infinity) in Long-Evans rat brain at 10 mg/kg, ip by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 19. | ALA4326377 | ADME | Ratio of drug level in Long-Evans rat brain to plasma at 10 mg/kg, ip by LCMS/MS analysis | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature | |
| 20. | ALA4326378 | Functional | Decrease in alcohol self administration in Long-Evans rat assessed as alcohol intake at 5 mg/kg, ip administered 30 mins prior to a self-administration session (Rvb = 0.87 +/- 0.11 g/kg) | Rattus norvegicus | 1 | ALA4325833 | organism-based format | Scientific Literature |
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