| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4356730 | B | Binding affinity to recombinant human His/SUMO-tagged STAT3 (127 to 688 residues) expressed in Escherichia coli Rosetta (DE3) incubated for 1 hr by fluorescence polarization assay | Homo sapiens | 10 | assay format | Scientific Literature | ||
| 2. | ALA4356733 | B | Protac activity at CRBN/STAT3 in human MOLM16 cells assessed as degradation of STAT3 incubated for 4 hrs by Western blot analysis | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 3. | ALA4356742 | B | Protac activity at CRBN/STAT3 in human SUDHL1 cells assessed as degradation of STAT3 incubated for 16 hrs by Western blot analysis | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 4. | ALA4356743 | F | Antiproliferative activity against human MOLM16 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 5. | ALA4356744 | F | Antiproliferative activity against human SUDHL1 cells assessed as reduction in cell viability incubated for 4 days by cell-titer glo luminescent assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 6. | ALA4356745 | B | Protac activity at CRBN/STAT3 in human MOLM16 cells assessed as degradation of STAT3 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4356747 | B | Protac activity at CRBN/STAT1 in human MOLM16 cells assessed as degradation of STAT1 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4356748 | B | Protac activity at CRBN/STAT2 in human MOLM16 cells assessed as degradation of STAT2 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4356749 | B | Protac activity at CRBN/STAT4 in human MOLM16 cells assessed as degradation of STAT4 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4356750 | B | Protac activity at CRBN/STAT5A in human MOLM16 cells assessed as degradation of STAT5A at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4356751 | B | Protac activity at CRBN/STAT5B in human MOLM16 cells assessed as degradation of STAT5B at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4356752 | B | Protac activity at CRBN/STAT6 in human MOLM16 cells assessed as degradation of STAT6 at 0.01 to 10 uM incubated for 4 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4356759 | B | Protac activity at CRBN/STAT3 in human SUDHL1 cells assessed as degradation of STAT3 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4356761 | B | Protac activity at CRBN/STAT1 in human SUDHL1 cells assessed as degradation of STAT1 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4356762 | B | Protac activity at CRBN/STAT2 in human SUDHL1 cells assessed as degradation of STAT2 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4356763 | B | Protac activity at CRBN/STAT4 in human SUDHL1 cells assessed as degradation of STAT4 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4356764 | B | Protac activity at CRBN/STAT5A in human SUDHL1 cells assessed as degradation of STAT5A at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4356765 | B | Protac activity at CRBN/STAT5B in human SUDHL1 cells assessed as degradation of STAT5B at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4356766 | B | Protac activity at CRBN/STAT6 in human SUDHL1 cells assessed as degradation of STAT6 at 0.01 to 10 uM incubated for 18 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4356773 | B | Selectivity index, ratio of protac activity at CRBN/STAT1 in human MOLM16 cells to protac activity at CRBN/STAT3 in human MOLM16 cells | Homo sapiens | 1 | cell-based format | Scientific Literature |
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