| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4394028 | Functional | Analgesic activity in Albino Swiss CD-1 mouse model of CCI-induced neuropathic pain assessed as reduction in paw lifting latency time at 5 to 10 mg/kg, ip administered 7 days after CCI measured at 95 to 185 mins by Cold plate test | Mus musculus | 1 | ALA4393658 | organism-based format | Scientific Literature | |
| 2. | ALA4394031 | Binding | Displacement of [3H]-8-OH-DPAT from human recombinant 5-HT1A receptor expressed in HEK293 cells after 1 hr by microbeta scintillation counting method | Homo sapiens | 29 | ALA4393658 | cell-based format | Scientific Literature | |
| 3. | ALA4394032 | Binding | Displacement of [3H] ketanserin from human recombinant 5-HT2A receptor expressed in CHOK1 cells after 1 hr by microbeta scintillation counting method | Homo sapiens | 29 | ALA4393658 | cell-based format | Scientific Literature | |
| 4. | ALA4394033 | Binding | Displacement of [3H] LSD from human recombinant 5-HT6 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method | Homo sapiens | 29 | ALA4393658 | cell-based format | Scientific Literature | |
| 5. | ALA4394034 | Binding | Displacement of [3H]-5-CT from human recombinant 5-HT7B receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method | Homo sapiens | 29 | ALA4393658 | cell-based format | Scientific Literature | |
| 6. | ALA4394035 | Binding | Displacement of [3H] raclopride from human recombinant D2L receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting method | Homo sapiens | 29 | ALA4393658 | cell-based format | Scientific Literature | |
| 7. | ALA4394042 | Functional | Agonist activity at 5-HT7 receptor (unknown origin) expressed in N1E-115 cells assessed as intracellular cAMP response time by confocal laser scanning microscopy | Homo sapiens | 3 | ALA4393658 | cell-based format | Scientific Literature | |
| 8. | ALA4394043 | Functional | Effect on cAMP response in mouse N1E-115 cells at 10 uM by confocal laser scanning microscopy | Mus musculus | 3 | ALA4393658 | cell-based format | Scientific Literature | |
| 9. | ALA4394044 | ADME | Permeability of compound at pH 7.4 by PAMPA | 3 | ALA4393658 | assay format | Scientific Literature | ||
| 10. | ALA4394045 | ADME | Inhibition of recombinant human Pgp assessed as effect on basal Pgp activity at 100 uM measured after 40 mins by Pgp-Glo luminescence assay | Homo sapiens | 1 | ALA4393658 | single protein format | Scientific Literature | |
| 11. | ALA4394046 | ADME | Inhibition of human CYP3A4 measured after 30 mins in presence of NADPH regeneration system by luminescent CYP3A4 P450-Glo assay | Homo sapiens | 2 | ALA4393658 | single protein format | Scientific Literature | |
| 12. | ALA4394047 | ADME | Metabolic stability in human liver microsomes assessed as metabolite formation in presence of NADPH measured after 120 mins by UPLC-MS analysis | Homo sapiens | 1 | ALA4393658 | microsome format | Scientific Literature | |
| 13. | ALA4394048 | ADME | Cytotoxicity against human HEK293 cells assessed as decrease in cell viability at 10 to 100 uM measured after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4393658 | cell-based format | Scientific Literature | |
| 14. | ALA4394049 | ADME | Cytotoxicity against human HepG2 cells assessed as decrease in cell viability at 100 uM measured after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4393658 | cell-based format | Scientific Literature | |
| 15. | ALA4394062 | Functional | Analgesic activity in Albino Swiss CD-1 mouse model of CCI-induced neuropathic pain assessed as increase in paw withdrawal threshold at 10 to 20 mg/kg, ip administered 7 days after CCI measured at 30 to 90 mins post-dose by Von Frey test | Mus musculus | 1 | ALA4393658 | organism-based format | Scientific Literature | |
| 16. | ALA4394063 | Functional | Analgesic activity in Albino Swiss CD-1 mouse model of CCI-induced neuropathic pain assessed as reduction in paw lifting latency time at 5 to 20 mg/kg, ip administered 7 days after CCI measured at 35 mins post-dose by Cold plate test | Mus musculus | 1 | ALA4393658 | organism-based format | Scientific Literature | |
| 17. | ALA4394064 | Functional | Analgesic activity in Albino Swiss CD-1 mouse model of CCI-induced neuropathic pain at 10 mg/kg, ip administered 7 days after CCI measured at 180 mins by Von Frey test | Mus musculus | 1 | ALA4393658 | organism-based format | Scientific Literature | |
| 18. | ALA4394065 | Functional | Antipyretic activity in Albino Swiss CD-1 mouse model of CCI-induced neuropathic pain assessed as effect on rectal temperature at 10 to 20 mg/kg, ip administered after 7 days after CCI measured at 15 to 100 mins by thermistor probe based assay | Mus musculus | 1 | ALA4393658 | organism-based format | Scientific Literature | |
| 19. | ALA4394066 | Functional | Antipyretic activity in Albino Swiss CD-1 mouse model of CCI-induced neuropathic pain assessed as effect on rectal temperature at 5 mg/kg, ip administered after 7 days after CCI measured by thermistor probe based assay | Mus musculus | 1 | ALA4393658 | organism-based format | Scientific Literature | |
| 20. | ALA4394067 | Functional | Agonist activity at 5-HT7 receptor (unknown origin) expressed in N1E-115 cells assessed as intracellular cAMP response amplitude by confocal laser scanning microscopy | Homo sapiens | 3 | ALA4393658 | cell-based format | Scientific Literature |
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