# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4411746 | P | Solubility of the compound in phosphate buffer at pH 7.2 at 10 mg/ml after 24 hrs by HPLC-UV method | 12 | ALA4411269 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4411747 | B | Inhibition of LMP7 in human MOLT4 cells by ELISA | Homo sapiens | 12 | ALA4411269 | cell-based format | Scientific Literature | |
3. | ALA4411748 | B | Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISA | Homo sapiens | 12 | ALA4411269 | cell-based format | Scientific Literature | |
4. | ALA4411749 | B | Inhibition of LMP2 in human MOLT4 cells by ELISA | Homo sapiens | 12 | ALA4411269 | cell-based format | Scientific Literature | |
5. | ALA4411750 | B | Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISA | Homo sapiens | 12 | ALA4411269 | cell-based format | Scientific Literature | |
6. | ALA4411751 | B | Inhibition of MECL1 in human MOLT4 cells by ELISA | Homo sapiens | 12 | ALA4411269 | cell-based format | Scientific Literature | |
7. | ALA4411752 | B | Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISA | Homo sapiens | 12 | ALA4411269 | cell-based format | Scientific Literature | |
8. | ALA4411753 | B | Inhibition of LMP7 in mouse A20 cells by ELISA | Mus musculus | 12 | ALA4411269 | cell-based format | Scientific Literature | |
9. | ALA4411754 | B | Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISA | Mus musculus | 12 | ALA4411269 | cell-based format | Scientific Literature | |
10. | ALA4411755 | B | Inhibition of LMP2 in mouse A20 cells by ELISA | Mus musculus | 12 | ALA4411269 | cell-based format | Scientific Literature | |
11. | ALA4411756 | B | Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISA | Mus musculus | 12 | ALA4411269 | cell-based format | Scientific Literature | |
12. | ALA4411757 | B | Inhibition of MECL1 in mouse A20 cells by ELISA | Mus musculus | 12 | ALA4411269 | cell-based format | Scientific Literature | |
13. | ALA4411758 | B | Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISA | Mus musculus | 12 | ALA4411269 | cell-based format | Scientific Literature | |
14. | ALA4411760 | B | Selectivity ratio of IC50 for MECL1 in mouse A20 cells to IC50 for MECL1 in human MOLT4 cells | 1 | ALA4411269 | cell-based format | Scientific Literature | ||
15. | ALA4411763 | A | Cytotoxicity in human PBMC assessed as reduction in cell viability at 250 nM relative to control | Homo sapiens | 1 | ALA4411269 | cell-based format | Scientific Literature | |
16. | ALA4411766 | F | Antiinflammatory activity in human PBMC assessed as reduction in LPS-stimulated TNF-alpha expression at 250 nM preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4411269 | cell-based format | Scientific Literature | |
17. | ALA4411767 | F | Antiinflammatory activity in human PBMC assessed as reduction in LPS-stimulated IL-6 expression at 250 nM preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4411269 | cell-based format | Scientific Literature | |
18. | ALA4411768 | F | Antiinflammatory activity in human PBMC assessed as reduction in LPS-stimulated p40 subunit of IL-12/33 expression at 250 nM preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4411269 | cell-based format | Scientific Literature | |
19. | ALA4411769 | F | Antiinflammatory activity in human PBMC assessed as reduction in anti-CD3/CD28 antibody-stimulated TNF-alpha expression at 250 nM preincubated for 1 hr followed by anti-CD3/CD28 antibody stimulation measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4411269 | cell-based format | Scientific Literature | |
20. | ALA4411770 | F | Antiinflammatory activity in human PBMC assessed as reduction in anti-CD3/CD28 antibody-stimulated IFN-gamma expression at 250 nM preincubated for 1 hr followed by anti-CD3/CD28 antibody stimulation measured after 24 hrs by ELISA | Homo sapiens | 3 | ALA4411269 | cell-based format | Scientific Literature |