| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4381499 | F | Photo-activated cytotoxicity against mouse B16-F10-luc2 cells assessed as cell viability at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by MTT assay relative to control | Mus musculus | 4 | ALA4376887 | cell-based format | Scientific Literature | |
| 2. | ALA4381500 | A | Cytotoxicity against mouse B16-F10-luc2 cells assessed as cell viability at 1 uM incubated for 24 hrs under dark condition by MTT assay relative to control | Mus musculus | 2 | ALA4376887 | cell-based format | Scientific Literature | |
| 3. | ALA4381501 | F | Photo-activated cytotoxicity against mouse B16-F10-luc2 cells assessed as reduction in cell viability preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by MTT assay | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 4. | ALA4381502 | F | Induction of apoptosis in mouse B16-F10-luc2 cells assessed as decrease in viable cells at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 5. | ALA4381503 | F | Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in late apoptotic cells at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 6. | ALA4381504 | F | Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in necrotic cells at 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 7. | ALA4381505 | F | Induction of apoptosis in mouse B16-F10-luc2 cells assessed as decrease in viable cells at 1 uM measured after 24 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 8. | ALA4381506 | F | Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in late apoptotic cells at 1 uM measured after 24 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 9. | ALA4381507 | F | Induction of apoptosis in mouse B16-F10-luc2 cells assessed as increase in necrotic cells at 1 uM measured after 24 hrs by Alexa Fluor 488 Annexin V/Dead Cell staining based flow cytometry | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 10. | ALA4381508 | F | Induction of ROS generation in ethanol assessed as reduction in DPBF absorbance at 410 nm at 1 uM preincubated for 10 mins followed by 342 J cm'-2 light irradiation for 15 mins and measured at 5 mins interval for 15 mins by spectrometric method | 3 | ALA4376887 | assay format | Scientific Literature | ||
| 11. | ALA4381509 | F | Induction of singlet oxygen generation in ethanol at 1 uM preincubated for 10 mins followed by 342 J cm'-2 light irradiation for 15 mins and measured at 5 mins interval for 15 mins by spectrometric method | 2 | ALA4376887 | assay format | Scientific Literature | ||
| 12. | ALA4381510 | F | Induction of reactive oxygen species generation in mouse B16-F10-luc2 cells at 10 uM preincubated for 3 hrs followed by compound washout prior to DHFA addition for 1 hr and subsequent 22.8 J cm'-2 light irradiation for 60 secs post media washout and measured immediately by fluorescence assay | Mus musculus | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 13. | ALA4381511 | F | Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as tumor growth at 100 uM, iv administered on day 1, 2, 7, and 9 measured for 12 days relative to control | Mus musculus | 1 | ALA4376887 | organism-based format | Scientific Literature | |
| 14. | ALA4381513 | F | Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as tumor growth at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 measured for 12 days relative to control | Mus musculus | 1 | ALA4376887 | organism-based format | Scientific Literature | |
| 15. | ALA4381514 | F | Antitumor activity against mouse B16-F10-luc2 cells implanted in SCID mouse assessed as reduction in tumor growth at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 measured on day 13 | Mus musculus | 2 | ALA4376887 | organism-based format | Scientific Literature | |
| 16. | ALA4381515 | T | Toxicity in mouse B16-F10-luc2 cells implanted SCID mouse assessed as effect on body weight at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 | Mus musculus | 1 | ALA4376887 | organism-based format | Scientific Literature | |
| 17. | ALA4381516 | T | Acute toxicity in mouse B16-F10-luc2 cells implanted SCID mouse at 100 uM, iv administered 30 mins prior to 68.4 J cm'-2 light irradiation for 3 mins on day 1, 2, 7, and 9 | Mus musculus | 1 | ALA4376887 | organism-based format | Scientific Literature | |
| 18. | ALA4381517 | F | Photo-activated cytotoxicity against human MCF7 cells assessed as reduction in cell viability up to 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by MTT assay | Homo sapiens | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 19. | ALA4381518 | F | Photo-activated cytotoxicity against human PANC1 cells assessed as reduction in cell viability up to 1 uM preincubated for 3 hrs followed by compound washout and subsequent 22.8 J cm'-2 light irradiation for 60 secs measured after 21 hrs by MTT assay | Homo sapiens | 1 | ALA4376887 | cell-based format | Scientific Literature | |
| 20. | ALA4381519 | A | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability up to 1 uM incubated for 24 hrs under dark condition by MTT assay | Homo sapiens | 2 | ALA4376887 | cell-based format | Scientific Literature |
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