# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4400874 | B | Induction of CRBN ubiquitin ligase-mediated IKZF1 degradation in human NCI-H929 cells up to 1000 nM by immunoblotting analysis | Homo sapiens | 5 | ALA4400516 | cell-based format | Scientific Literature | |
2. | ALA4400875 | B | Binding affinity to ePL-tagged CRBN (unknown origin) expressed in HEK293 cells assessed as increase in thermal stability after 1 hr by thermal shift assay | Homo sapiens | 2 | ALA4400516 | cell-based format | Scientific Literature | |
3. | ALA4400876 | F | Antiproliferative activity against human NCI-H929 cells after 72 hrs by WST-1 assay | Homo sapiens | 2 | ALA4400516 | cell-based format | Scientific Literature | |
4. | ALA4400877 | F | Antitumor activity against human TMD8 cells xenografted in CB-17/IcrCri SCID mouse assessed as tumor growth inhibition at 50 mg/kg, ip qd for 14 days measured during compound dosing | Homo sapiens | 1 | ALA4400516 | organism-based format | Scientific Literature | |
5. | ALA4400878 | T | Toxicity in CB-17/IcrCri SCID mouse xenografted with human TMD8 cells assessed as change in body weight at 50 mg/kg, ip qd for 14 days measured twice weekly during compound dosing | Mus musculus | 1 | ALA4400516 | organism-based format | Scientific Literature | |
6. | ALA4400889 | F | Antitumor activity against human TMD8 cells xenografted in CB-17/IcrCri SCID mouse assessed as tumor growth inhibition at 50 mg/kg, ip qd for 14 days measured after 14 days | Homo sapiens | 1 | ALA4400516 | organism-based format | Scientific Literature | |
7. | ALA4400890 | T | Toxicity in CB-17/IcrCri SCID mouse xenografted with human TMD8 cells assessed as adverse effect at 50 mg/kg, ip qd for 14 days | Mus musculus | 1 | ALA4400516 | organism-based format | Scientific Literature | |
8. | ALA4400891 | B | Induction of CRBN ubiquitin ligase-mediated IKZF3 degradation in human NCI-H929 cells up to 1000 nM by immunoblotting analysis | Homo sapiens | 5 | ALA4400516 | cell-based format | Scientific Literature |