# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4341882 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 13 | ALA4340547 | microsome format | Scientific Literature | |
2. | ALA4341883 | A | Unbound brain to plasma concentration ratio in mouse at 5 mg/kg, po | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature | |
3. | ALA4341884 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye and BzATP addition measured after 30 mins by fluorescence assay | Homo sapiens | 20 | ALA4340547 | cell-based format | Scientific Literature | |
4. | ALA4341885 | B | Antagonist activity at P2X7R in LPS-stimulated human THP1 cells assessed as inhibition of BzATP-induced IL-1beta release preincubated for 30 mins followed by BzATP stimulation and measured after 30 mins by sandwich ELISA | Homo sapiens | 20 | ALA4340547 | assay format | Scientific Literature | |
5. | ALA4341886 | A | Intrinsic clearance in mouse liver microsomes | Mus musculus | 13 | ALA4340547 | microsome format | Scientific Literature | |
6. | ALA4341887 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 13 | ALA4340547 | microsome format | Scientific Literature | |
7. | ALA4341888 | A | Apparent permeability across apical to basolateral side in MDCK cells expressing MDR | Canis lupus familiaris | 13 | ALA4340547 | cell-based format | Scientific Literature | |
8. | ALA4341889 | A | Efflux ratio of apparent permeability in MDCK cells expressing MDR | Canis lupus familiaris | 13 | ALA4340547 | cell-based format | Scientific Literature | |
9. | ALA4341890 | B | Antagonist activity at rat P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye and BzATP addition measured after 30 mins by fluorescence assay | Rattus norvegicus | 7 | ALA4340547 | single protein format | Scientific Literature | |
10. | ALA4341891 | B | Antagonist activity at mouse P2X7 receptor assessed as inhibition of BzATP-induced YO PRO dye uptake preincubated for 20 mins followed by YO PRO dye and BzATP addition measured after 30 mins by fluorescence assay | Mus musculus | 7 | ALA4340547 | single protein format | Scientific Literature | |
11. | ALA4341892 | B | Activity at human ERG | Homo sapiens | 2 | ALA4340547 | single protein format | Scientific Literature | |
12. | ALA4341893 | A | Protein binding in human plasma assessed as unbound fraction | Homo sapiens | 2 | ALA4340547 | cell-free format | Scientific Literature | |
13. | ALA4341894 | A | Protein binding in mouse plasma assessed as unbound fraction | Mus musculus | 2 | ALA4340547 | cell-free format | Scientific Literature | |
14. | ALA4341895 | A | Protein binding in rat plasma assessed as unbound fraction | Rattus norvegicus | 2 | ALA4340547 | cell-free format | Scientific Literature | |
15. | ALA4341896 | A | Dose normalized AUC in mouse at 0.5 mg/kg, po | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature | |
16. | ALA4341897 | A | Dose normalized AUC in mouse at 0.2 mg/kg, iv | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature | |
17. | ALA4341898 | A | Dose normalized Cmax in mouse at 0.5 mg/kg, po | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature | |
18. | ALA4341899 | A | Dose normalized Cmax in mouse at 0.2 mg/kg, iv | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature | |
19. | ALA4341900 | A | Terminal half life in mouse at 0.2 mg/kg, iv or 0.5 mg/kg, po | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature | |
20. | ALA4341901 | A | Clearance in mouse at 0.2 mg/kg, iv or 0.5 mg/kg, po | Mus musculus | 2 | ALA4340547 | organism-based format | Scientific Literature |