| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4433839 | B | Inhibition of human HCN4 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at 5 uM at holding potential of -80 mV by patch clamp assay relative to control | Homo sapiens | 8 | ALA4433219 | cell-based format | Scientific Literature | |
| 2. | ALA4433840 | B | Inhibition of human HCN4 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by patch clamp assay | Homo sapiens | 1 | ALA4433219 | cell-based format | Scientific Literature | |
| 3. | ALA4433841 | B | Inhibition of mouse HCN2 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by patch clamp assay | Mus musculus | 1 | ALA4433219 | cell-based format | Scientific Literature | |
| 4. | ALA4433842 | B | Inhibition of mouse HCN1 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by patch clamp assay | Mus musculus | 1 | ALA4433219 | cell-based format | Scientific Literature | |
| 5. | ALA4433843 | B | Selectivity ratio of EC50 for human HCN1 to EC50 for mouse HCN4 | 1 | ALA4433219 | assay format | Scientific Literature | ||
| 6. | ALA4433844 | B | Selectivity ratio of EC50 for human HCN2 to EC50 for mouse HCN4 | 1 | ALA4433219 | assay format | Scientific Literature | ||
| 7. | ALA4433845 | B | Inhibition of HCN4 in guinea pig single sinoatrial node assessed as reduction in hyperpolarization activated current at 10 uM at holding potential of -120 mV by patch clamp assay relative to control | Cavia porcellus | 1 | ALA4433219 | assay format | Scientific Literature | |
| 8. | ALA4433846 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as conduction time at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 4.8 +/- 0.60 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 9. | ALA4433847 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as conduction time at 10 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 4.8 +/- 0.60 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 10. | ALA4433848 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as maximum diastolic potential at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = -83.8 +/- 2.28 mV) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 11. | ALA4433849 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as maximum diastolic potential at 10 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = -83.8 +/- 2.28 mV) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 12. | ALA4433850 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential amplitude at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 104.1 +/- 2.7 mV) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 13. | ALA4433851 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential amplitude at 10 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 104.1 +/- 2.7 mV) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 14. | ALA4433852 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as Vmax at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 244.6 +/- 30.87 V/s) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 15. | ALA4433853 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as Vmax at 10 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 244.6 +/- 30.87 V/s) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 16. | ALA4433854 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential time duration at 90% of repolarization at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 212.5 +/- 16.25 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 17. | ALA4433855 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential time duration at 90% of repolarization at 10 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 212.5 +/- 16.25 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 18. | ALA4433856 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential time duration at 75% of repolarization at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 199.7 +/- 16.87 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 19. | ALA4433857 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential time duration at 75% of repolarization at 10 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 199.7 +/- 16.87 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature | |
| 20. | ALA4433858 | F | Effect on cardiac electrophysiological profile in Mongrel perfused dog heart left ventricular muscle stimulated at basic cycle length of 1000 milliseconds assessed as action potential time duration at 50% of repolarization at 1 uM measured after 25 mins by glass capillary microelectrode based electrophysiology assay (Rvb = 176 +/- 16.36 milliseconds) | Canis lupus familiaris | 1 | ALA4433219 | tissue-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!