# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4413684 | B | Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells at 200 nM using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay relative to control | Homo sapiens | 24 | ALA4411317 | cell-based format | Scientific Literature | |
2. | ALA4413685 | B | Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells at 40 nM using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay relative to control | Homo sapiens | 24 | ALA4411317 | cell-based format | Scientific Literature | |
3. | ALA4413686 | B | Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay | Homo sapiens | 24 | ALA4411317 | cell-based format | Scientific Literature | |
4. | ALA4413687 | A | Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay | Homo sapiens | 12 | ALA4411317 | cell-based format | Scientific Literature | |
5. | ALA4413688 | A | Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval for 20 mins by fluorescence assay | Homo sapiens | 12 | ALA4411317 | cell-based format | Scientific Literature | |
6. | ALA4413689 | A | Cytotoxicity against human LO2 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay relative to control | Homo sapiens | 4 | ALA4411317 | cell-based format | Scientific Literature | |
7. | ALA4413690 | A | Cytotoxicity against human LO2 cells assessed as cell viability at 50 uM after 48 hrs by MTT assay relative to control | Homo sapiens | 3 | ALA4411317 | cell-based format | Scientific Literature | |
8. | ALA4413692 | F | Hypoglycemic activity in Kunming mouse assessed as decrease in blood glucose AUC (0 to 120 mins) at 10 mg/kg, po administered as single dose treated for 30 mins prior to glucose load by OGTT relative to control | Mus musculus | 3 | ALA4411317 | organism-based format | Scientific Literature | |
9. | ALA4413693 | P | Retention time of the compound in water at 1 uM by LC/MS/MS method | 2 | ALA4411317 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4413694 | A | Retention time of the compound in rat plasma at 1 uM by LC/MS/MS method | Rattus norvegicus | 1 | ALA4411317 | cell-free format | Scientific Literature | |
11. | ALA4413695 | A | Drug metabolism in rat plasma assessed as (R)-2-((4-(3-Aminopiperidin-1-yl)-3-(but-2-yn-1-yl)-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)methyl)-6-fluorobenzoic acid hydrochloride formation at 1 uM after 30 mins by LC/MS/MS method | Rattus norvegicus | 1 | ALA4411317 | cell-free format | Scientific Literature | |
12. | ALA4413697 | F | Hypoglycemic activity in po dosed Kunming mouse assessed as decrease in blood glucose AUC (0 to 120 mins) administered as single dose treated for 30 mins prior to glucose load by OGTT | Mus musculus | 1 | ALA4411317 | organism-based format | Scientific Literature | |
13. | ALA4413698 | F | Hypoglycemic activity in Kunming mouse assessed as decrease in blood glucose AUC (0 to 120 mins) at 3 mg/kg, po administered as single dose treated for 30 mins prior to glucose load by OGTT relative to control | Mus musculus | 2 | ALA4411317 | organism-based format | Scientific Literature | |
14. | ALA4413699 | F | Hypoglycemic activity in Kunming mouse assessed as decrease in blood glucose AUC (0 to 120 mins) at 1 mg/kg, po administered as single dose treated for 30 mins prior to glucose load by OGTT relative to control | Mus musculus | 1 | ALA4411317 | organism-based format | Scientific Literature | |
15. | ALA5247222 | B | Inhibition of human recombinant DPP-4 | Homo sapiens | 9 | ALA5244277 | single protein format | Scientific Literature |