# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4416169 | F | Antiplasmodial activity against Plasmodium falciparum 3D7A erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation preincubated for 24 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by microbeta scintillation counting method | Plasmodium falciparum | 59 | ALA4414601 | organism-based format | Scientific Literature | |
2. | ALA4416170 | B | Inhibition of Plasmodium falciparum full length N-terminal His-tagged PKG expressed in Escherichia coli RosettaTM 2(DE3) pLysS cells using FAM-GRTGRRNSI-NH2 as substrate preincubated for 30 mins followed by ATP addition and measured after 30 mins by microfluidic mobility shift assay | Plasmodium falciparum | 57 | ALA4414601 | cell-based format | Scientific Literature | |
3. | ALA4416171 | P | Lipophilicity, LogD of compound by reverse phase HPLC analysis | 57 | ALA4414601 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4416172 | P | Aqueous solubility of compound | 57 | ALA4414601 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4416173 | B | Inhibition of human ERG expressed in CHO cells by Q-patch clamp assay | Homo sapiens | 40 | ALA4414601 | cell-based format | Scientific Literature | |
6. | ALA4416174 | A | Cytotoxicity against mouse L929 cells assessed as reduction in viability by dual luciferase reporter gene assay | Mus musculus | 57 | ALA4414601 | cell-based format | Scientific Literature | |
7. | ALA4416175 | A | Permeability of compound by PAMPA | 57 | ALA4414601 | assay format | Scientific Literature | ||
8. | ALA4416176 | A | Clearance in mouse liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by HPLC-MS/MS analysis | Mus musculus | 40 | ALA4414601 | microsome format | Scientific Literature | |
9. | ALA4416177 | A | Clearance in rat liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by HPLC-MS/MS analysis | Rattus norvegicus | 40 | ALA4414601 | microsome format | Scientific Literature | |
10. | ALA4416178 | A | Clearance in human liver microsomes at 0.5 uM measured up to 45 mins in presence of NADPH by HPLC-MS/MS analysis | Homo sapiens | 40 | ALA4414601 | microsome format | Scientific Literature | |
11. | ALA4416196 | T | Selectivity ratio of EC50 for cytotoxicity against mouse L929 cells to EC50 for Antiplasmodial activity against Plasmodium falciparum 3D7A erythrocytic stage | 1 | ALA4414601 | cell-based format | Scientific Literature | ||
12. | ALA4416197 | F | Antiplasmodial activity against Plasmodium falciparum 3D7A erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation preincubated for 24 to 120 hrs followed by subculture in absence of compound and measured after 21 to 28 days by microbeta scintillation counting method | Plasmodium falciparum | 3 | ALA4414601 | organism-based format | Scientific Literature |