| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4426501 | F | Agonist activity at human P2Y1R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 2. | ALA4426502 | B | Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)-phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate from human P2Y14R expressed in CHO cells at 3 uM measured after 15 mins by flow cytometric analysis | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 3. | ALA4426503 | F | Antagonist activity at human P2Y6R expressed in human 1321N1 cells assessed as inhibition of UDP-induced calcium mobilization at 10 uM preincubated for 30 mins followed by UDP addition measured after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4426504 | F | Antagonist activity at human P2Y1R expressed in human 1321N1 cells assessed as inhibition of MeSADP-induced calcium mobilization at 10 uM preincubated for 30 mins followed by MeSADP addition measured after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4426505 | F | Agonist activity at human P2Y1R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4426506 | F | Agonist activity at human P2Y2R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4426507 | F | Agonist activity at human P2Y4R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4426508 | F | Agonist activity at human P2Y11R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4426509 | F | Agonist activity at PAR1 (unknown origin) expressed in mouse KOLF cells assessed as calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4426510 | F | Agonist activity at human P2Y6R expressed in human 1321N1 cells assessed as calcium mobilization at 10 uM after 1 hr by FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4426511 | F | Antagonist activity at human P2Y1R expressed in human 1321N1 cells assessed as inhibition of 2-MeSADP-mediated calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4426512 | F | Antagonist activity at human P2Y2R expressed in human 1321N1 cells assessed as inhibition of UTP-induced calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4426513 | F | Antagonist activity at human P2Y4R expressed in human 1321N1 cells assessed as inhibition of UTP-induced calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4426514 | F | Antagonist activity at human P2Y11R expressed in human 1321N1 cells assessed as inhibition of ATP-induced calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4426515 | F | Antagonist activity at PAR1 (unknown origin) expressed in mouse KOLF cells assessed as inhibition of TRAP-induced calcium mobilization at 10 uM by PDSP assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4426523 | B | Displacement of 6-Amino-9-(2-carboxy-4-((6-(4-(4-(4-(4-(3-carboxy-6-(4-(trifluoromethyl)phenyl)-naphthalen-1-yl)phenyl)piperidin-1-yl)-butyl)-1H-1,2,3-triazol-1-yl)hexyl)carbamoyl)-phenyl)-3-iminio-5-sulfo-3H-xanthene-4-sulfonate from human P2Y14R expressed in CHO cells measured after 15 mins by flow cytometric analysis | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 17. | ALA4426524 | F | Antagonist activity at human P2Y14R expressed in CHO cells assessed as inhibition of UDPG-mediated reduction of forskolin-induced cAMP production at 1 uM after 15 mins by by competitive enzyme-linked immunoassay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4619168 | B | Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from HA-tagged mouse P2Y14 expressed in HEK293 cells measured after 30 mins by FACScalibur flow cytometry analysis | Mus musculus | 8 | cell-based format | Scientific Literature | ||
| 19. | ALA4619169 | B | Displacement of Alexafluor488 labeled 4-(4-(1-(4-(1-(6-(4-(6-amino-3-imino-4,5-disulfo-3H-xanthen-9-yl)-3-carboxybenzamido)hexyl)-1H-1,2,3-triazol-4-yl)butyl)piperidin-4-yl)phenyl)-7-(4-(trifluoromethyl)phenyl)-2-naphthoic acid from human P2Y14 expressed in CHO cells measured after 30 mins by FACScalibur flow cytometry analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 20. | ALA4619175 | F | Antinociceptive activity in ip dosed ICR mouse model of chronic constriction injury-induced neuropathic pain assessed as inhibition of mechanical allodynia administered 7 days post-surgery and measured after 1 hr post-dose by Von Frey assay | Mus musculus | 3 | organism-based format | Scientific Literature |
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