| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4335365 | F | Antiviral activity against MERS-CoV infected in human Caco2 cells assessed as inhibition of viral replication measured at 18 hrs post-infection by plaque formation assay | Middle East respiratory syndrome-related coronavirus | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 2. | ALA4335366 | F | Antiviral activity against GFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells assessed as reduction in viral infection at 10 uM preincubated for 2 hrs followed by viral infection and measured after 48 hrs by epifluorescence microscopic analysis relative to control | Hepacivirus hominis | 36 | ALA4334439 | organism-based format | Scientific Literature | |
| 3. | ALA4335367 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days by qRT-PCR analysis | Hepacivirus hominis | 36 | ALA4334439 | organism-based format | Scientific Literature | |
| 4. | ALA4335368 | F | Antiviral activity against HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells after 2 days by renilla luciferase reporter gene assay | Hepacivirus hominis | 2 | ALA4334439 | organism-based format | Scientific Literature | |
| 5. | ALA4335369 | A | Cytotoxicity against human Huh7.5.1 cells assessed as decrease in cell viability after 48 hrs by WST1 assay | Homo sapiens | 34 | ALA4334439 | cell-based format | Scientific Literature | |
| 6. | ALA4335370 | T | Selectivity index, ratio of CC50 for human Huh7.5.1 cells to EC50 for EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutant infected in human Huh7.5.1 cells | 34 | ALA4334439 | cell-based format | Scientific Literature | ||
| 7. | ALA4335371 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of telaprevir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 8. | ALA4335372 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of IFNalpha by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 9. | ALA4335373 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of ribavirin by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 10. | ALA4335374 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of cyclosporin A by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 11. | ALA4335375 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of boceprevir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 12. | ALA4335376 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of daclatasvir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 13. | ALA4335377 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as reduction in viral RNA level after 2 days in presence of sofosbuvir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 14. | ALA4335378 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of boceprevir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 15. | ALA4335379 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of cyclosporin A by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 16. | ALA4335380 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of ribavirin by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 17. | ALA4335381 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of sofosbuvir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 18. | ALA4335382 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of IFNalpha by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 19. | ALA4335383 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of daclatasvir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature | |
| 20. | ALA4335384 | F | Antiviral activity against EGFP-fused HCV JFH-1 harboring K78E/E2-G451R/NS3-M260K/NS5A-T462I mutation infected in human Huh7.5.1 cells assessed as combination index after 2 days in presence of telaprevir by qRT-PCR analysis | Hepacivirus hominis | 1 | ALA4334439 | organism-based format | Scientific Literature |
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