| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4373433 | F | Decrease in hepatic ACOT4 mRNA level in high fat diet fed C57BL/6J mouse at 40 mg/kg, ip administered every 2 days for 11 weeks by qPCR analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4373434 | B | Inhibition of Wnt3a activated Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells harboring TCF/LEF-responsive luciferase preincubated with cells followed by Wnt3a addition and measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 3. | ALA4373435 | A | Growth inhibition of HEK293 cells harboring Wnt after 24 hrs by CellTiter-Fluor assay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
| 4. | ALA4373436 | A | Growth inhibition of unstimulated HEK293 cells up to 100 uM after 72 hrs by CellTiter-Fluor assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4373437 | B | Inhibition of LiCl activated Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells harboring TCF/LEF-responsive luciferase preincubated with cells followed by LiCl addition and measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4373438 | B | Stabilization of Axin1 protein in HEK293 cells assessed as increase in cytoplasmic punctas at 1 uM after 14 hrs by DAPI staining based confocal microscopic method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4373439 | B | Inhibition of Wnt3a activated Wnt/beta-catenin/Axin signaling (unknown origin) expressed in HEK293 cells assessed as stabilization of Axin1 protein at 1 to 10 uM after 2 hrs by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4373440 | B | Inhibition of Wnt3a activated Wnt/beta-catenin/Axin signaling (unknown origin) expressed in HEK293 cells assessed as degradation of beta-catenin by measuring decrease in beta-catenin protein expression at 1 to 10 uM after 2 hrs by Western blot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4373441 | B | Inhibition of Wnt/beta-catenin/Axin signaling (unknown origin) expressed in HEK293 cells assessed as decrease in CycD1 mRNA level after 48 hrs by qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4373442 | B | Inhibition of Wnt/beta-catenin/Axin signaling (unknown origin) expressed in HEK293 cells assessed as decrease in Axin2 mRNA level after 48 hrs by qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4373443 | B | Inhibition of LiCl-activated Wnt/beta-catenin/Axin signaling (unknown origin) expressed in HEK293 cells assessed as degradation of beta-catenin by measuring decrease in beta-catenin protein expression after 24 hrs by Western blot method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 12. | ALA4373444 | B | Inhibition of 25 to 50 mM LiCl activated Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells harboring TCF/LEF-responsive luciferase at 0.1 uM preincubated with cells followed by LiCl addition and measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4373445 | B | Inhibition of Wnt (unknown origin)/FLAG-tagged human beta-catenin signaling expressed in HEK293 cells harboring TCF/LEF-responsive luciferase at 100 nM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4373446 | B | Inhibition of Wnt (unknown origin)/FLAG-tagged human beta-catenin S33Y mutant signaling expressed in HEK293 cells harboring TCF/LEF-responsive luciferase at 100 nM measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4373447 | B | Inhibition of Wnt/beta-catenin/Axin signaling (unknown origin) expressed in HEK293 cells assessed as increase in Axin binding to beta-catenin after 12 hrs by immunoprecipitation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4373448 | B | Inhibition of Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells assessed as increase in GSK3beta binding to beta-catenin after 12 hrs by immunoprecipitation method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4373449 | B | Inhibition of Wnt/beta-catenin signaling (unknown origin) expressed in HEK293 cells harboring TCF/LEF-responsive luciferase assessed as luminescence at 20 nM measured after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4373450 | B | Inhibition of Wnt/beta-catenin signaling (unknown origin) expressed in GSK3beta knock down HEK293 cells harboring TCF/LEF-responsive luciferase assessed as luminescence at 20 nM measured after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4373451 | B | Inhibition of Wnt/beta-catenin signaling (unknown origin) expressed in Axin1 knock down HEK293 cells harboring TCF/LEF-responsive luciferase assessed as luminescence at 20 nM measured after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4373452 | B | Inhibition of Wnt/beta-catenin signaling (unknown origin) expressed in CK1alpha knock down HEK293 cells harboring TCF/LEF-responsive luciferase assessed as luminescence at 20 nM measured after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!