# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4382069 | Binding | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels at 100 nM incubated for 36 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
2. | ALA4382070 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels at 100 nM incubated for 36 hrs by Western blot analysis | Homo sapiens | 2 | ALA4376901 | cell-based format | Scientific Literature | |
3. | ALA4382071 | Unassigned | Drug metabolism assessed as photoisomerization to cis-isomer after exposure to UV-C light and measured after 1 hr by UV-visible absorption spectra analysis | 1 | ALA4376901 | assay format | Scientific Literature | ||
4. | ALA4382072 | Unassigned | Drug metabolism assessed as photoisomerization to trans-isomer after exposure to UV-C light and measured up to 120 mins by UV-visible absorption spectra analysis | 1 | ALA4376901 | assay format | Scientific Literature | ||
5. | ALA4382073 | Unassigned | Drug metabolism assessed as photoisomerization to cis-isomer after exposure to white light light up to 240 mins by UV-visible absorption spectra analysis | 1 | ALA4376901 | assay format | Scientific Literature | ||
6. | ALA4382074 | Physicochemical | Half life for spontaneous thermal relaxation under dark condition at 25 degC | 1 | ALA4376901 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4382075 | Physicochemical | Stability in presence of 20 mM of GSH reduced in DMSO/PBS buffer (1:1) solution incubated for 48 hrs | 1 | ALA4376901 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4382076 | Functional | Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
9. | ALA4382077 | Functional | Cytotoxicity against human K562 cells assessed as inhibition of cell viability incubated for 48 hrs by Cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
10. | ALA4382078 | Functional | Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by Cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
11. | ALA4382079 | Functional | Cytotoxicity against human HCT116 cells assessed as inhibition of cell viability incubated for 48 hrs by Cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
12. | ALA4382080 | Functional | Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by Cell-titer-Glo luminescent cell viability assay | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
13. | ALA4382081 | Binding | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels pre-treated with ABL inhibitor dasatinib followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
14. | ALA4382082 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels pre-treated with ABL inhibitor dasatinib followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
15. | ALA4382085 | Binding | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels pre-treated with lenalidomide followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
16. | ALA4382086 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels pre-treated with lenalidomide followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
17. | ALA4382087 | Binding | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels pre-treated with NEDD8-activating enzyme (NAE) inhibitor MLN4924 followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
18. | ALA4382088 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels pre-treated with NEDD8-activating enzyme (NAE) inhibitor MLN4924 followed by compound addition at 250 nM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
19. | ALA4382089 | Binding | Protac activity at CRBN/BCR-ABL in human K562 cells assessed as reduction in BCR-ABL protein levels incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature | |
20. | ALA4382090 | Binding | Protac activity at CRBN/ABL in human K562 cells assessed as reduction in ABL protein levels incubated for 36 hrs by Western blot analysis | Homo sapiens | 1 | ALA4376901 | cell-based format | Scientific Literature |