| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4369475 | B | Inhibition of rat NAAA expressed in HEK293 cells using heptadecenoylethanolamide as substrate after 30 mins HPLC-MS/MS analysis | Rattus norvegicus | 50 | ALA4368874 | cell-based format | Scientific Literature | |
| 2. | ALA4369476 | B | Inhibition of rat FAAH expressed in HEK293 cells using [3H]AEA as substrate after 30 mins HPLC-MS/MS analysis | Rattus norvegicus | 8 | ALA4368874 | cell-based format | Scientific Literature | |
| 3. | ALA4369479 | B | Reversible inhibition of rat NAAA expressed in HEK293 cells at 5 uM using heptadecenoylethanolamide as substrate after 8 hrs by rapid dilution based HPLC-MS/MS analysis | Rattus norvegicus | 1 | ALA4368874 | cell-based format | Scientific Literature | |
| 4. | ALA4369480 | B | Competitive inhibition of rat NAAA expressed in HEK293 cells assessed as substrate Vmax at 5 uM using heptadecenoylethanolamide as substrate after 30 mins by Michaelis Menten plot analysis (Rvb = 5.89 +/- 0.12 nmol/min/mg protein) | Rattus norvegicus | 1 | ALA4368874 | cell-based format | Scientific Literature | |
| 5. | ALA4369481 | B | Competitive inhibition of rat NAAA expressed in HEK293 cells assessed as substrate Km at 5 uM using heptadecenoylethanolamide as substrate after 30 mins by Michaelis Menten plot analysis (Rvb = 207 +/- 16 uM) | Rattus norvegicus | 1 | ALA4368874 | cell-based format | Scientific Literature | |
| 6. | ALA4369482 | P | Half life in pH 8 tris-HCl buffer by HPLC analysis | 1 | ALA4368874 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4369483 | P | Half life in pH 5 phosphate buffer by HPLC analysis | 1 | ALA4368874 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4369484 | A | Half life in rat 80% plasma by HPLC analysis | Rattus norvegicus | 1 | ALA4368874 | cell-free format | Scientific Literature | |
| 9. | ALA4369485 | F | Anti-inflammatory activity in mouse model of LPS-induced acute lung injury assessed as reduction in leukocytes in lungs at 30 mg/kg, po qd for 5 days by hematoxylin and eosin staining-based light microscopic analysis | Mus musculus | 1 | ALA4368874 | organism-based format | Scientific Literature | |
| 10. | ALA4369486 | F | Anti-inflammatory activity in mouse model of LPS-induced acute lung injury assessed as reduction in lung edema at 30 mg/kg, po qd for 5 days by hematoxylin and eosin staining-based light microscopic analysis | Mus musculus | 1 | ALA4368874 | organism-based format | Scientific Literature | |
| 11. | ALA4369487 | F | Anti-inflammatory activity in mouse model of LPS-induced acute lung injury at 30 mg/kg, po qd for 5 days co-treated with 2 mg/kg, ip bid PPAR-alpha antagonist MK886 by hematoxylin and eosin staining-based light microscopic analysis | Mus musculus | 1 | ALA4368874 | organism-based format | Scientific Literature |
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