| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4329480 | A | Metabolic stability in human liver microsomes measured immediately after compound addition in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4325910 | microsome format | Scientific Literature | |
| 2. | ALA4329481 | A | Metabolic stability in simulated intestinal fluid at pH 6.8 measured after 16 hrs by HPLC analysis | 1 | ALA4325910 | assay format | Scientific Literature | ||
| 3. | ALA4329482 | A | Metabolic stability in simulated intestinal fluid at pH 6.8 measured after 24 hrs by HPLC analysis | 1 | ALA4325910 | assay format | Scientific Literature | ||
| 4. | ALA4329483 | A | Metabolic stability in simulated intestinal fluid at pH 6.8 measured after 6 hrs by HPLC analysis | 1 | ALA4325910 | assay format | Scientific Literature | ||
| 5. | ALA4329484 | A | Metabolic stability in simulated intestinal fluid at pH 6.8 measured after 4 hrs by HPLC analysis | 1 | ALA4325910 | assay format | Scientific Literature | ||
| 6. | ALA4329485 | A | Metabolic stability in simulated intestinal fluid at pH 6.8 measured immediately after compound addition by HPLC analysis | 1 | ALA4325910 | assay format | Scientific Literature | ||
| 7. | ALA4329486 | A | Metabolic stability in simulated intestinal fluid at pH 6.8 measured after 2 hrs by HPLC analysis | 1 | ALA4325910 | assay format | Scientific Literature | ||
| 8. | ALA4329487 | F | Inhibition of cellular glucose output in dexamethasone-induced insulin resistant human L02 cells assessed as insulin-stimulated glucose uptake at 10 uM preincubated for 24 hrs followed by insulin stimulation measured after 24 hrs by glucose oxidase method (Rvb = 4.5 +/- 0.7%) | Homo sapiens | 14 | ALA4325910 | cell-based format | Scientific Literature | |
| 9. | ALA4329488 | F | Induction of insulin-stimulated 2-NBDG uptake in TNF-alpha-induced insulin resistant mouse 3T3L1 cells at 10 uM preincubated for 48 hrs followed by 2-NBDG addition measured after 30 mins in presence of insulin by fluorescence assay | Mus musculus | 7 | ALA4325910 | cell-based format | Scientific Literature | |
| 10. | ALA4329489 | F | Induction of insulin-stimulated 2-NBDG uptake in TNF-alpha-induced insulin resistant mouse 3T3L1 cells preincubated for 48 hrs followed by 2-NBDG addition measured after 30 mins in presence of insulin by fluorescence assay | Mus musculus | 2 | ALA4325910 | cell-based format | Scientific Literature | |
| 11. | ALA4329490 | F | Antidiabetic activity in spontaneous db/db BKS.Cg-Dock7m +/+ Leprdb/J mouse assessed as decrease in fasting blood glucose level at 10 to 20 mg/kg, po administered as daily dose via gavage for 18 days measured on day 9 post last dose by glucometric analysis | Mus musculus | 1 | ALA4325910 | organism-based format | Scientific Literature | |
| 12. | ALA4329492 | F | Antidiabetic activity in spontaneous db/db BKS.Cg-Dock7m +/+ Leprdb/J mouse assessed as decrease in blood glucose AUC at 10 to 20 mg/kg, po administered as daily dose via gavage for 18 days measured on day 12 up to 120 mins post glucose challenge by oral glucose tolerance test | Mus musculus | 1 | ALA4325910 | organism-based format | Scientific Literature | |
| 13. | ALA4329494 | T | Toxicity in spontaneous db/db BKS.Cg-Dock7m +/+ Leprdb/J mouse assessed as body weight gain at 27 umol/kg, po administered as daily dose via gavage treated for 18 days measured post last dose (Rvb = 5.6 +/- 2.1 g) | Mus musculus | 2 | ALA4325910 | organism-based format | Scientific Literature | |
| 14. | ALA4329495 | T | Toxicity in spontaneous db/db BKS.Cg-Dock7m +/+ Leprdb/J mouse assessed as body weight gain at 13.5 umol/kg, po administered as daily dose via gavage treated for 18 days measured post last dose (Rvb = 5.6 +/- 2.1 g) | Mus musculus | 1 | ALA4325910 | organism-based format | Scientific Literature | |
| 15. | ALA4329496 | F | Effect on lipid metabolism in spontaneous db/db BKS.Cg-Dock7m +/+ Leprdb/J mouse assessed as decrease in serum triglyceride level at 27 umol/kg, po administered as daily dose via gavage for 18 days | Mus musculus | 1 | ALA4325910 | organism-based format | Scientific Literature | |
| 16. | ALA4329497 | F | Effect on lipid metabolism in spontaneous db/db BKS.Cg-Dock7m +/+ Leprdb/J mouse assessed as increase in serum HDL level at 27 umol/kg, po administered as daily dose via gavage for 18 days | Mus musculus | 1 | ALA4325910 | organism-based format | Scientific Literature | |
| 17. | ALA4329498 | F | Induction of adipogenesis in mouse 3T3L1 preadipocytes assessed as increase in intracellular triglyceride level at 10 uM treated every other day up to day 14 by AdipoRed staining based confocal microscopic method | Mus musculus | 2 | ALA4325910 | cell-based format | Scientific Literature | |
| 18. | ALA4329499 | F | Induction of nitric oxide mediated increase in insulin-stimulated 2-NBDG uptake in TNF-alpha-induced insulin resistant mouse 3T3L1 cells at 3 to 10 uM preincubated for 48 hrs followed by 2-NBDG addition measured after 30 mins in presence of insulin by fluorescence assay | Mus musculus | 1 | ALA4325910 | cell-based format | Scientific Literature | |
| 19. | ALA4329500 | F | Induction of nitric oxide mediated increase in insulin-stimulated 2-NBDG uptake in TNF-alpha-induced insulin resistant mouse 3T3L1 cells at 3 to 10 uM preincubated for 48 hrs followed by 2-NBDG addition measured after 30 mins in presence of nitric oxide scavenger C-PTIO by fluorescence assay | Mus musculus | 1 | ALA4325910 | cell-based format | Scientific Literature | |
| 20. | ALA4329501 | F | Induction of nitric oxide production in TNF-alpha-induced insulin resistant mouse 3T3L1 cells at 3 to 10 uM after 0.5 to 6 hrs by DAF-FM-2DA dye based fluorescence assay | Mus musculus | 1 | ALA4325910 | cell-based format | Scientific Literature |
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