# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4392163 | A | Displacement of [3H]N-methylspiperone from human D2L receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
2. | ALA4392164 | B | Displacement of [3H]N-methylspiperone from human D3 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
3. | ALA4392165 | B | Displacement of [3H]N-methylspiperone from human D4.4 receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
4. | ALA4392173 | A | Agonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay relative to dopamine | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
5. | ALA4392174 | A | Agonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
6. | ALA4392175 | A | Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay relative to dopamine | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
7. | ALA4392176 | A | Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
8. | ALA4392177 | F | Agonist activity at human D4 receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay relative to dopamine | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
9. | ALA4392178 | F | Agonist activity at human D4 receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
10. | ALA4392179 | F | Antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay relative to dopamine | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
11. | ALA4392180 | F | Antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins by Eu-cAMP tracer based TR-FRET assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
12. | ALA4392181 | B | Selectivity ratio of EC50 for agonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation to EC50 for agonist activity at human D4 receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced cAMP accumulation | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
13. | ALA4392182 | B | Selectivity ratio of IC50 for antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP accumulation to IC50 for antagonist activity at human D4 receptor expressed in CHOK1 cells assessed as suppression of dopamine-induced inhibition of forskolin-stimulated cAMP accumulation | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
14. | ALA4392183 | A | Agonist activity at human D2L receptor expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by luminescence assay relative to control | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
15. | ALA4392184 | A | Agonist activity at human D2L receptor expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by luminescence assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
16. | ALA4392185 | A | Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 90 mins by luminescence assay relative to control | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
17. | ALA4392186 | A | Antagonist activity at human D2L receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 90 mins by luminescence assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
18. | ALA4392187 | B | Agonist activity at human D3 receptor expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by luminescence assay relative to control | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
19. | ALA4392188 | B | Agonist activity at human D3 receptor expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by luminescence assay | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature | |
20. | ALA4392189 | B | Antagonist activity at human D3 receptor expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 90 mins by luminescence assay relative to control | Homo sapiens | 19 | ALA4390675 | cell-based format | Scientific Literature |