# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4384658 | B | Inhibition of MNK in mouse 3T3L1 cells assessed as reduction of eIF4E phosphorylation at 3 uM after 2 hrs by Western blot analysis | Mus musculus | 28 | ALA4382255 | cell-based format | Scientific Literature | |
2. | ALA4384659 | B | Inhibition of MNK in mouse 3T3L1 cells assessed as reduction of eIF4E phosphorylation at 0.1 uM after 2 hrs by Western blot analysis | Mus musculus | 6 | ALA4382255 | cell-based format | Scientific Literature | |
3. | ALA4384660 | B | Inhibition of mTORC2 in mouse 3T3L1 cells assessed as reduction in PKB phosphorylation at Ser473 residue at 0.1 to 5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | cell-based format | Scientific Literature | |
4. | ALA4384661 | B | Inhibition of mTORC1 in mouse 3T3L1 cells assessed as reduction in rpS6 phosphorylation at Ser240/244 residues at 0.1 to 5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | cell-based format | Scientific Literature | |
5. | ALA4384662 | B | Inhibition of mTORC1 in mouse 3T3L1 cells assessed as reduction in 4EBP1 at Ser65 residue phosphorylation at 0.1 to 5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | cell-based format | Scientific Literature | |
6. | ALA4384665 | B | Inhibition of MNK1 in C57BL/6J mouse embryonic fibroblasts assessed as decrease in eIF4E phosphorylation at 5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | single protein format | Scientific Literature | |
7. | ALA4384666 | B | Inhibition of MNK2 in C57BL/6J mouse embryonic fibroblasts assessed as decrease in eIF4E phosphorylation at 5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | single protein format | Scientific Literature | |
8. | ALA4384667 | B | Inhibition of MNK1 in C57BL/6J mouse embryonic fibroblasts assessed as decrease in eIF4E phosphorylation at 0.1 to 0.3 uM after 2 hrs by Western blot analysis relative to control | Mus musculus | 2 | ALA4382255 | single protein format | Scientific Literature | |
9. | ALA4384668 | B | Inhibition of MNK2 in C57BL/6J mouse embryonic fibroblasts assessed as decrease in eIF4E phosphorylation at 0.1 to 0.3 uM after 2 hrs by Western blot analysis relative to control | Mus musculus | 2 | ALA4382255 | single protein format | Scientific Literature | |
10. | ALA4384669 | B | Inhibition of MNK1 in MNK2-knockout C57BL/6J mouse embryonic fibroblasts assessed as decrease in eIF4E phosphorylation at 0.3 to 5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | single protein format | Scientific Literature | |
11. | ALA4384670 | B | Inhibition of GST-fused MNK1a (unknown origin) expressed in HEK293 cells using eIF4E as substrate after 30 mins by Western blot analysis | Homo sapiens | 2 | ALA4382255 | cell-based format | Scientific Literature | |
12. | ALA4384671 | B | Inhibition of GST-fused MNK2a (unknown origin) expressed in HEK293 cells using eIF4E as substrate after 30 mins by Western blot analysis | Homo sapiens | 2 | ALA4382255 | cell-based format | Scientific Literature | |
13. | ALA4384672 | B | Inhibition of MNK in human MDA-MB-231 cells assessed as decrease in eIF4E phosphorylation at 1 uM after 2 hrs by Western blot analysis | Homo sapiens | 2 | ALA4382255 | cell-based format | Scientific Literature | |
14. | ALA4384673 | F | Antimigratory activity against human MDA-MB-231 cells after 24 hrs by DAPI staining-based Transwell assay | Homo sapiens | 2 | ALA4382255 | cell-based format | Scientific Literature | |
15. | ALA4384674 | A | Cell cycle arrest in human MDA-MB-231 cells at 0.3 to 6 uM after 2 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 1 | ALA4382255 | cell-based format | Scientific Literature | |
16. | ALA4384675 | A | Cell cycle arrest in human MDA-MB-231 cells assessed as accumulation of cells at sub-G0 phase at 0.3 to 6 uM after 2 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 1 | ALA4382255 | cell-based format | Scientific Literature | |
17. | ALA4384676 | A | Effect on total eIF4E protein level in mouse 3T3L1 cells at 3 uM after 2 hrs by Western blot analysis | Mus musculus | 25 | ALA4382255 | cell-based format | Scientific Literature | |
18. | ALA4384677 | B | Stimulation of ERK1/2 phosphorylation at Thr202/Tyr204 residues in mouse 3T3L1 cells at 0.1 to 5 uM after 2 hrs by Western blot analysis | Mus musculus | 1 | ALA4382255 | cell-based format | Scientific Literature | |
19. | ALA4384678 | B | Stimulation of ERK signalling in mouse 3T3L1 cells assessed as increase in RSK phosphorylation at Ser308 residue at 0.1 to 5 uM after 2 hrs by Western blot analysis | Mus musculus | 1 | ALA4382255 | cell-based format | Scientific Literature | |
20. | ALA4384679 | B | Inhibition of MNK2 in MNK1-knockout C57BL/6J mouse embryonic fibroblasts assessed as decrease in eIF4E phosphorylation at 0.5 uM after 2 hrs by Western blot analysis | Mus musculus | 2 | ALA4382255 | single protein format | Scientific Literature |