| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4403811 | B | Activation of human Kv7.2 expressed in CHO cells assessed as increase in current amplitude at 10 uM measured at holding potential of 0 mV by whole cell patch clamp electrophysiology assay relative to control | Homo sapiens | 45 | ALA4402547 | cell-based format | Scientific Literature | |
| 2. | ALA4403812 | B | Activation of human Kv7.2 expressed in CHO cells assessed as increase in current amplitude at 10 uM measured at holding potential of -40 mV by whole cell patch clamp electrophysiology assay relative to control | Homo sapiens | 45 | ALA4402547 | cell-based format | Scientific Literature | |
| 3. | ALA4403815 | B | Activation of human Kv7.2 expressed in CHO cells assessed as maximal steady-state increase in current amplitude at 10 uM measured after 200 secs at holding potential of -40 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 2 | ALA4402547 | cell-based format | Scientific Literature | |
| 4. | ALA4403816 | P | Lipophilicity, log P of the compound | 3 | ALA4402547 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4403817 | P | Hydrophobicity of compound assessed as self aggregating property by measuring decrease in ratio between fluorescence intensity peaks at 372 nm to 383 nm at 0.7 to 100 uM by pyrene based fluorescence spectroscopic method | 3 | ALA4402547 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4403821 | B | Activation of human Kv7.2 W236L mutant expressed in CHO cells assessed as channel current amplitude at 10 uM measured at holding potential of -40 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 4 | ALA4402547 | cell-based format | Scientific Literature | |
| 7. | ALA4403822 | B | Activation of ICA-insensitive human Kv7.2 F168L mutant expressed in CHO cells assessed as increase in channel current amplitude at 10 uM measured at holding potential of -40 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 4 | ALA4402547 | cell-based format | Scientific Literature | |
| 8. | ALA4403823 | B | Activation of human Kv7.2/Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 9. | ALA4403824 | B | Activation of human Kv7.2 expressed in CHO cells assessed as delta V at 10 uM by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 10. | ALA4403825 | B | Activation of human Kv7.2/Kv7.3 expressed in CHO cells assessed as delta V at 10 uM by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 11. | ALA4403826 | B | Activation of human Kv7.3 expressed in CHO cells assessed as delta V at 30 uM by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 12. | ALA4403827 | A | Activation of human Kv7.4 expressed in CHO cells assessed as delta V at 10 uM by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 13. | ALA4403828 | A | Activation of human Kv7.5 expressed in CHO cells assessed as delta V at 10 uM by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 14. | ALA4403829 | B | Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 15. | ALA4403830 | B | Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 16. | ALA4403831 | A | Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 17. | ALA4403832 | A | Activation of human Kv7.5 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
| 18. | ALA4403835 | U | Photostability of compound in pH 7.4 buffer assessed as compound degradation at 100 ug/ml incubated for 6 hrs under natural solar light-irradiation by HPLC analysis relative to control | 7 | ALA4402547 | assay format | Scientific Literature | ||
| 19. | ALA4403838 | U | Photostability of compound in pH 7.4 buffer assessed as compound degradation at 100 ug/ml incubated for 2 hrs under natural solar light-irradiation by HPLC analysis relative to control | 7 | ALA4402547 | assay format | Scientific Literature | ||
| 20. | ALA4403839 | U | Photostability of compound in pH 7.4 buffer assessed as compound degradation at 100 ug/ml incubated for 4 hrs under natural solar light-irradiation by HPLC analysis relative to control | 7 | ALA4402547 | assay format | Scientific Literature |
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