| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4400289 | B | Displacement of [3H]methyl- N-alpha methylhistamine dihydrochloride from human recombinant H3 receptor expressed in CHOK1 cells measured after 30 mins by liquid scintillation counter method | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 2. | ALA4400290 | B | Displacement of [3H]methyl- N-alpha methylhistamine dihydrochloride from Sprague-Dawley rat cerebral cortex H3 receptor measured after 30 mins by scintillation counter method | Rattus norvegicus | 12 | assay format | Scientific Literature | ||
| 3. | ALA4400291 | B | Displacement of [3H]quinuclidinyl benzilate from Wistar rat cortex muscarinic acetylcholine receptor by liquid scintillation counter method | Rattus norvegicus | 5 | assay format | Scientific Literature | ||
| 4. | ALA4400294 | B | Inhibition of human ERG | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 5. | ALA4400296 | F | In vivo antagonist activity at H3 receptor in po dosed Wistar rat assessed as inhibition of imetit induced dipsogenia preincubated for 30 mins followed by imetit administration at 3 mg/kg,sc | Rattus norvegicus | 4 | organism-based format | Scientific Literature | ||
| 6. | ALA4400297 | A | Fraction of drug metabolized in human microsomes | Homo sapiens | 9 | microsome format | Scientific Literature | ||
| 7. | ALA4400298 | A | Fraction of drug metabolized in rat microsomes | Rattus norvegicus | 9 | microsome format | Scientific Literature | ||
| 8. | ALA4400299 | A | Oral bioavailability in Wistar rat at 10 mg/kg measured after 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4400300 | A | Tmax in Wistar rat brain at 10 mg/kg, po measured after 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4400301 | A | Ratio of AUC (0 to infinity) in Wistar rat brain to plasma at 10 mg/kg, po measured after 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4400302 | A | Ratio of half-life in Wistar rat brain to plasma at 10 mg/kg, po measured after 5 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4400303 | F | Cognitive enhancement in scopolamine-induced amnesia Wistar rat model assessed as increase in memory retrieval at 3 mg/kg, po with scopolamine treatment for 23 hrs followed by compound administration measured after 1 hr by water labyrinth relative to control | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4400304 | P | Solubility of compound in DMSO | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA4400305 | P | Kinetic solubility of compound | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4400306 | P | Lipophilicity, logP of compound | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 16. | ALA4400307 | P | Partition coefficient, logD of compound at pH 7.4 | 1 | small-molecule physicochemical format | Scientific Literature |
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