# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4305534 | Binding | Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide22 substrate phosphorylation incubated for 90 mins | Homo sapiens | 21 | ALA4304751 | assay format | Scientific Literature | |
2. | ALA4305537 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 1 uM after 30 mins relative to control | Mus musculus | 2 | ALA4304751 | microsome format | Scientific Literature | |
3. | ALA4305538 | Physicochemical | Solubility in buffer at pH 6.8 | 2 | ALA4304751 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4305539 | ADME | Protein binding in BALB/c mouse serum at 10 ug/mL incubated for 4 hrs under shaking condition by LC/MS/MS analysis | Mus musculus | 2 | ALA4304751 | cell-free format | Scientific Literature | |
5. | ALA4305540 | ADME | Effective permeability of compound at 5 uM after 24 hrs at pH 7.4 by LC/MS/MS based PAMPA assay | 2 | ALA4304751 | assay format | Scientific Literature | ||
6. | ALA4305541 | ADME | Total plasma clearance in BALB/cAnNCrlCrlj mouse at 1 mg/kg, iv after 24 hrs | Mus musculus | 2 | ALA4304751 | organism-based format | Scientific Literature | |
7. | ALA4305542 | ADME | AUC in BALB/cAnNCrlCrlj mouse at 10 mg/kg, po administered via gavage after 24 hrs | Mus musculus | 2 | ALA4304751 | organism-based format | Scientific Literature | |
8. | ALA4305543 | ADME | Cmax in BALB/cAnNCrlCrlj mouse at 10 mg/kg, po administered via gavage after 24 hrs | Mus musculus | 2 | ALA4304751 | organism-based format | Scientific Literature | |
9. | ALA4305544 | ADME | Oral bioavailability in BALB/cAnNCrlCrlj mouse at 10 mg/kg administered via gavage after 24 hrs | Mus musculus | 2 | ALA4304751 | organism-based format | Scientific Literature | |
10. | ALA4305563 | Physicochemical | Solubility in FaSSIF | 2 | ALA4304751 | small-molecule physicochemical format | Scientific Literature |