| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4339429 | B | Selectivity ratio of IC50 for recombinant human AKR1C2 expressed in Escherichia coli BL21 (D3) to IC50 for recombinant human AKR1C3 expressed in Escherichia coli BL21 (D3) | Homo sapiens | 56 | assay format | Scientific Literature | ||
| 2. | ALA4339430 | A | Inhibition of recombinant human AKR1C2 expressed in Escherichia coli BL21 (D3) using S-tetralol as substrate in presence of NADP+ by UV-spectrophotometric method | Homo sapiens | 53 | assay format | Scientific Literature | ||
| 3. | ALA4339431 | B | Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 (D3) using S-tetralol as substrate in presence of NADP+ by UV-spectrophotometric method | Homo sapiens | 56 | assay format | Scientific Literature | ||
| 4. | ALA4339469 | B | Inhibition of recombinant human AKR1C3 expressed in Escherichia coli BL21 measured after 1.5 hrs by TR-FRET assay | Homo sapiens | 9 | assay format | Scientific Literature | ||
| 5. | ALA4430089 | B | Inhibition of recombinant AKR1C3 (unknown origin) assessed as reduction in S-tetralol catalyzed oxidation in presence of NADPH by fluorescence assay | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 6. | ALA4430090 | B | Inhibition of recombinant AKR1C2 (unknown origin) assessed as reduction in S-tetralol catalyzed oxidation in presence of NADPH by fluorescence assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 7. | ALA4430091 | B | Selectivity ratio of IC50 for recombinant AKR1C2 (unknown origin) to IC50 for recombinant AKR1C3 (unknown origin) | Homo sapiens | 6 | assay format | Scientific Literature | ||
| 8. | ALA4430148 | F | Cytotoxicity against human HL60 cells assessed as reduction in cell viability up to 100 uM at 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4430151 | F | Cytotoxicity against human KG1a cells expressing AKR1C3 assessed as reduction in cell viability at >25 uM at 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4430153 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring reduction in cell viability at 0.1 uM coincubated with etoposide at 1 uM after 72 hrs by MTS assay (Rvb = 40%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4430155 | B | Inhibition of AKR1C3 in human KG1a cells assessed as potentiation of etoposide-induced cytotoxicity by measuring reduction in cell viability at 0.1 uM coincubated with etoposide at 1 uM after 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4430157 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring reduction in cell viability pre-treated with 0.1 to 1 uM compound for 24 hrs followed by 1 uM etoposide exposure for additional 72 hrs by MTS assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4430158 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring combination index cotreated at 72 hrs by MTS assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4430159 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring dose reduction index cotreated at 72 hrs by MTS assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA4430160 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 after 24 to 72 hrs by MTS assay (Rvb = 1.16 uM) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 16. | ALA4430161 | B | Inhibition of AKR1C3 in human KG1a cells assessed as potentiation of etoposide-induced cytotoxicity by measuring combination index cotreated at 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4430162 | B | Inhibition of AKR1C3 in human KG1a cells assessed as potentiation of etoposide-induced cytotoxicity by measuring dose reduction index cotreated at 72 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4430163 | B | Inhibition of AKR1C3 in human KG1a cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 cotreated at 72 hrs by MTS assay (Rvb = 6.70 uM) | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4430164 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring combination index pre-treated with compound for 24 hrs followed by etoposide exposure for additional 72 hrs by MTS assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4430165 | B | Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring dose reduction index pre-treated with compound for 24 hrs followed by etoposide exposure for additional 72 hrs by MTS assay | Homo sapiens | 4 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!