# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325024 | F | Antibacterial activity against Escherichia coli ATCC 25922 assessed as reduction in bacterial growth by broth microdilution method | Escherichia coli | 29 | organism-based format | Scientific Literature | ||
2. | ALA4325025 | F | Antibacterial activity against quinolone-resistant Klebsiella pneumoniae T6474 expressing broad spectrum beta-lactamase assessed as reduction in bacterial growth by broth microdilution method | Klebsiella pneumoniae | 29 | organism-based format | Scientific Literature | ||
3. | ALA4325026 | F | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in bacterial growth by broth microdilution method | Pseudomonas aeruginosa | 29 | organism-based format | Scientific Literature | ||
4. | ALA4325027 | B | Inhibition of recombinant Escherichia coli LpxC (1 to 300 residues) C125S mutant expressed in Escherichia coli BL21 AI assessed as change in melting temperature at 25 uM by Sypro orange dye based differential scanning fluorimetry | Escherichia coli | 21 | assay format | Scientific Literature | ||
5. | ALA4325028 | B | Inhibition of recombinant Pseudomonas aeruginosa LpxC (1 to 299 residues) C40S mutant expressed in Escherichia coli BL21 AI assessed as change in melting temperature at 25 uM by Sypro orange dye based differential scanning fluorimetry | Pseudomonas aeruginosa | 21 | assay format | Scientific Literature | ||
6. | ALA4325029 | P | n-Octanol/phopshate buffer partition coefficient, log D of the compound at pH 7.4 by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4325030 | P | Dissociation constant, pKa of compound by UV metric assay | 20 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4325031 | P | Solubility of compound at pH 4 incubated for 24 hrs by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
9. | ALA4325032 | P | Solubility of compound at pH 7 incubated for 24 hrs by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
10. | ALA4325033 | P | Solubility of compound at pH 9 incubated for 24 hrs by LC/UV analysis | 29 | small-molecule physicochemical format | Scientific Literature | |||
11. | ALA4325034 | A | Metabolic stability in rat hepatocytes assessed as total intrinsic clearance at 1 uM measured per million cells | Rattus norvegicus | 12 | cell-based format | Scientific Literature | ||
12. | ALA4325035 | A | Metabolic stability in rat liver microsomes assessed as total intrinsic clearance at 1 uM | Rattus norvegicus | 12 | microsome format | Scientific Literature | ||
13. | ALA4325036 | F | In vivo antibacterial activity against Escherichia coli ATCC 25922 A-935 infected in NMRI or ICR CD1 mouse neutropenic thigh infection model assessed as change in log10CFU at 150 mg/kg, sc administered 2 hrs post infection and measured per thigh after 24 hrs by serial dilution method | Escherichia coli | 9 | organism-based format | Scientific Literature | ||
14. | ALA4325037 | A | Protein binding in mouse plasma at 1 uM by rapid equilibrium dialysis method | Mus musculus | 9 | cell-free format | Scientific Literature | ||
15. | ALA4325039 | A | AUC (0 to 24 hrs) in mouse at 150 mg/kg, sc measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
16. | ALA4325041 | A | Free AUC (0 to 24 hrs) in mouse at 150 mg/kg, sc measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 8 | organism-based format | Scientific Literature | ||
17. | ALA4325042 | A | Metabolic stability in human hepatocytes assessed as total intrinsic clearance at 1 uM measured per million cells | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
18. | ALA4325043 | A | Metabolic stability in human liver microsomes assessed as total intrinsic clearance at 1 uM | Homo sapiens | 7 | microsome format | Scientific Literature | ||
19. | ALA4325044 | A | Protein binding in rat plasma at 1 uM by rapid equilibrium dialysis method | Rattus norvegicus | 7 | cell-free format | Scientific Literature | ||
20. | ALA4325045 | A | Unbound clearance in Wistar rat at 10 mg/kg, iv measured up to 24 hrs by LC/MS/MS analysis | Rattus norvegicus | 6 | organism-based format | Scientific Literature |