# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4422590 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD depletion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4422591 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring maximal ADPR conversion pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis | Homo sapiens | 4 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4422592 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring NAD consumption at 150 uM pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis relative to control | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4422593 | B | Inhibition of StrepTag-tagged human SARM1 TIR (561 to 724 residues) expressed in NRK1-HEK293T cells assessed as reduction in NADase activity by measuring ADPR production at 150 uM pre-incubated up to 120 mins before NAD+ addition and further incubated for 60 mins by HPLC analysis | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data |