# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4334555 | Binding | Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 14 | ALA4334421 | cell-based format | Scientific Literature | |
2. | ALA4334556 | Binding | Inhibition of recombinant full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 cells using Z-Lys(Ac)-AMC as substrate incubated for 90 mins followed by trypsin addition and measured after 30 mins by fluorescence based assay | Homo sapiens | 14 | ALA4334421 | cell-based format | Scientific Literature | |
3. | ALA4334557 | Binding | Selectivity index, ratio of IC50 for recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells to IC50 for recombinant full length N-terminal GST-tagged human HDAC6 expressed in baculovirus infected Sf9 cells | Homo sapiens | 14 | ALA4334421 | cell-based format | Scientific Literature | |
4. | ALA4334558 | Functional | Antiproliferative activity against human CHP134 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay | Homo sapiens | 12 | ALA4334421 | cell-based format | Scientific Literature | |
5. | ALA4334559 | Functional | Antiproliferative activity against human IMR32 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay | Homo sapiens | 12 | ALA4334421 | cell-based format | Scientific Literature | |
6. | ALA4334560 | Functional | Antiproliferative activity against human SK-N-AS cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay | Homo sapiens | 12 | ALA4334421 | cell-based format | Scientific Literature | |
7. | ALA4334561 | Functional | Antiproliferative activity against human NB-1 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer Glo assay | Homo sapiens | 12 | ALA4334421 | cell-based format | Scientific Literature | |
8. | ALA4334562 | Functional | Antiproliferative activity against human G55T2 cells assessed as reduction in cell viability incubated for 72 hrs by WST-8 assay | Homo sapiens | 12 | ALA4334421 | cell-based format | Scientific Literature | |
9. | ALA4334563 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in G0/G1 phase at 1 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 49.9 %) | Homo sapiens | 1 | ALA4334421 | cell-based format | Scientific Literature | |
10. | ALA4334564 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in S phase at 1 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 14.7 %) | Homo sapiens | 1 | ALA4334421 | cell-based format | Scientific Literature | |
11. | ALA4334565 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in G2/M phase at 1 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 26.8 %) | Homo sapiens | 1 | ALA4334421 | cell-based format | Scientific Literature | |
12. | ALA4334566 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in subG0 phase at 1 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 4.5 %) | Homo sapiens | 1 | ALA4334421 | cell-based format | Scientific Literature | |
13. | ALA4334567 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in G0/G1 phase at 3 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 49.9 %) | Homo sapiens | 2 | ALA4334421 | cell-based format | Scientific Literature | |
14. | ALA4334568 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in S phase at 3 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 14.7 %) | Homo sapiens | 2 | ALA4334421 | cell-based format | Scientific Literature | |
15. | ALA4334569 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in G2/M phase at 3 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 26.8 %) | Homo sapiens | 2 | ALA4334421 | cell-based format | Scientific Literature | |
16. | ALA4334570 | Functional | Cell cycle arrest in human G55T2 cells assessed as accumulation in subG0 phase at 3 uM incubated for 72 hrs by propidium iodide based flow cytometry (Rvb = 4.5 %) | Homo sapiens | 2 | ALA4334421 | cell-based format | Scientific Literature |