# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4398027 | B | Displacement of [3H]muscimol from GABA(A) receptor in Sprague-Dawley rat cortical synaptic membranes by liquid scintillation counting | Rattus norvegicus | 14 | ALA4396887 | assay format | Scientific Literature | |
2. | ALA4398028 | B | Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay | Homo sapiens | 13 | ALA4396887 | cell-based format | Scientific Literature | |
3. | ALA4398029 | B | Agonist activity at recombinant human GABA-A alpha1beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay | Homo sapiens | 16 | ALA4396887 | cell-based format | Scientific Literature | |
4. | ALA4398030 | B | Agonist activity at recombinant human GABA-A alpha1beta2gamma2S receptor transiently expressed in human tsA201 cells assessed as GABA-induced maximum response incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay relative to GABA | Homo sapiens | 16 | ALA4396887 | cell-based format | Scientific Literature | |
5. | ALA4398031 | B | Agonist activity at recombinant human GABA-A alpha3beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay | Homo sapiens | 16 | ALA4396887 | cell-based format | Scientific Literature | |
6. | ALA4398032 | B | Agonist activity at recombinant human GABA-A alpha3beta2gamma2S receptor transiently expressed in human tsA201 cells assessed as GABA-induced maximum response incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay relative to GABA | Homo sapiens | 15 | ALA4396887 | cell-based format | Scientific Literature | |
7. | ALA4398033 | B | Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay | Homo sapiens | 16 | ALA4396887 | cell-based format | Scientific Literature | |
8. | ALA4398034 | B | Agonist activity at recombinant human GABA-A alpha4beta2gamma2S receptor transiently expressed in human tsA201 cells assessed as GABA-induced maximum response incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay relative to GABA | Homo sapiens | 15 | ALA4396887 | cell-based format | Scientific Literature | |
9. | ALA4398035 | B | Agonist activity at recombinant human GABA-A alpha5beta2gamma2S receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay | Homo sapiens | 16 | ALA4396887 | cell-based format | Scientific Literature | |
10. | ALA4398036 | B | Agonist activity at recombinant human GABA-A alpha5beta2gamma2S receptor transiently expressed in human tsA201 cells assessed as GABA-induced maximum response incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay relative to GABA | Homo sapiens | 15 | ALA4396887 | cell-based format | Scientific Literature | |
11. | ALA4398037 | B | Agonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells assessed as GABA-induced maximum response incubated for 30 mins and measured up to 90 secs by FMP dye based FLIPR membrane potential blue assay relative to GABA | Homo sapiens | 12 | ALA4396887 | cell-based format | Scientific Literature | |
12. | ALA4398038 | P | Ionization constant, pKa2 of the compound at 1 mM by potentiometric titration assay | 9 | ALA4396887 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4398052 | B | Inhibition of human GAT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting method | Homo sapiens | 11 | ALA4396887 | cell-based format | Scientific Literature | |
14. | ALA4398053 | B | Inhibition of human GAT2 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting method | Homo sapiens | 11 | ALA4396887 | cell-based format | Scientific Literature | |
15. | ALA4398054 | B | Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting method | Homo sapiens | 11 | ALA4396887 | cell-based format | Scientific Literature | |
16. | ALA4398055 | B | Inhibition of human BGT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake incubated for 3 mins by liquid scintillation counting method | Homo sapiens | 11 | ALA4396887 | cell-based format | Scientific Literature | |
17. | ALA4398056 | B | Inhibition of human GAT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake at 100 uM incubated for 3 mins by liquid scintillation counting method relative to control | Homo sapiens | 10 | ALA4396887 | cell-based format | Scientific Literature | |
18. | ALA4398057 | B | Inhibition of human GAT2 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake at 100 uM incubated for 3 mins by liquid scintillation counting method relative to control | Homo sapiens | 10 | ALA4396887 | cell-based format | Scientific Literature | |
19. | ALA4398058 | B | Inhibition of human GAT3 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake at 100 uM incubated for 3 mins by liquid scintillation counting method relative to control | Homo sapiens | 10 | ALA4396887 | cell-based format | Scientific Literature | |
20. | ALA4398059 | B | Inhibition of human BGT1 expressed in Flp-In CHO cells assessed as reduction in [3H]GABA uptake at 100 uM incubated for 3 mins by liquid scintillation counting method relative to control | Homo sapiens | 10 | ALA4396887 | cell-based format | Scientific Literature |