# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4434268 | B | Agonist activity at human Kv7.2/Kv7.3 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
2. | ALA4434269 | B | Agonist activity at human Kv7.3/Kv7.5 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
3. | ALA4434270 | B | Agonist activity at human Kv7.4 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
4. | ALA4434271 | B | Agonist activity at human Kv7.4/Kv7.5 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
5. | ALA4434272 | B | Selectivity index, ratio of EC2x for human Kv7.4/5 expressed in HEK293 cells to EC2x for EC2x for human Kv7.2/3 expressed in HEK293 cells | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
6. | ALA5116577 | B | Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assay | Homo sapiens | 7 | ALA5113435 | single protein format | Scientific Literature | |
7. | ALA5116578 | B | Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials at 5 uM by SyncroPatch assay | Homo sapiens | 22 | ALA5113435 | single protein format | Scientific Literature | |
8. | ALA5116579 | B | Agonist activity at Kv7.2 W236L mutant (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials at 5 uM by SyncroPatch assay | Homo sapiens | 22 | ALA5113435 | assay format | Scientific Literature | |
9. | ALA5116580 | B | Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assay relative to control | Homo sapiens | 7 | ALA5113435 | single protein format | Scientific Literature | |
10. | ALA5116581 | B | Agonist activity at Kv7.2 W236L mutant (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assay relative to control | Homo sapiens | 7 | ALA5113435 | assay format | Scientific Literature | |
11. | ALA5116582 | B | Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFP | Homo sapiens | 4 | ALA5113435 | cell-based format | Scientific Literature | |
12. | ALA5116583 | B | Agonist activity at Kv7.4 (unknown origin) expressed in CHO cells co-expressing GFP | Homo sapiens | 4 | ALA5113435 | cell-based format | Scientific Literature | |
13. | ALA5116584 | B | Agonist activity at Kv7.5 (unknown origin) expressed in CHO cells co-expressing GFP | Homo sapiens | 4 | ALA5113435 | cell-based format | Scientific Literature | |
14. | ALA5116586 | B | Selectivity index, ratio of EC50 for agonist activity at Kv7.4 (unknown origin) expressed in CHO cells co-expressing GFP to EC50 for agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFP | Homo sapiens | 1 | ALA5113435 | cell-based format | Scientific Literature | |
15. | ALA5116587 | B | Selectivity index, ratio of EC50 for agonist activity at Kv7.5 (unknown origin) expressed in CHO cells co-expressing GFP to EC50 for agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFP | Homo sapiens | 1 | ALA5113435 | cell-based format | Scientific Literature |