| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4433996 | B | Agonist activity at TLR2 in mouse BV2 cells assessed as stimulation of NFkappaB pathway by measuring increase in IkappaBalpha phosphorylation incubated for 12 hrs by Western blot analysis | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 2. | ALA4433997 | B | Agonist activity at TLR2 in mouse RAW264.7 cells assessed as induction of IL-6 production incubated for 24 hrs by ELISA | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 3. | ALA4433998 | B | Agonist activity at TLR2 in wild type mouse BMDM cells assessed as induction of NFkappaB pathway activation by measuring increase in TNF-alpha mRNA expression by qRT-PCR analysis | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 4. | ALA4433999 | A | Effect on IL-6 mRNA expression in TLR2-/- mouse BMDM cells at 0.1 to 1 uM by qRT-PCR analysis | Mus musculus | 4 | ALA4433228 | cell-based format | Scientific Literature | |
| 5. | ALA4434000 | F | Effect on IL-6 production in TLR2-/- mouse BMDM cells at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 7 | ALA4433228 | cell-based format | Scientific Literature | |
| 6. | ALA4434001 | F | Effect on TNFalpha production in TLR2-/- mouse BMDM cells at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 3 | ALA4433228 | cell-based format | Scientific Literature | |
| 7. | ALA4434002 | B | Agonist activity at TLR2 in mouse BV2 cells assessed as increase in IL-6 secretion at 1 uM incubated for 24 hrs in presence of NF-kappaB inhibitor triptolide by ELISA | Mus musculus | 3 | ALA4433228 | cell-based format | Scientific Literature | |
| 8. | ALA4434003 | B | Activation of TLR2 in in wild type mouse BMDM cells assessed as stimulation of IL-6 production at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 3 | ALA4433228 | cell-based format | Scientific Literature | |
| 9. | ALA4434004 | A | Effect on IL-6 mRNA expression in TLR2-/- mouse BMDM cells at 0.1 to 1 uM by qRT-PCR analysis | Mus musculus | 4 | ALA4433228 | cell-based format | Scientific Literature | |
| 10. | ALA4434005 | B | Agonist activity at TLR2 in wild type mouse BMDM cells assessed as induction of NFkappaB pathway activation by measuring increase in IL-6 mRNA expression by qRT-PCR analysis | Mus musculus | 4 | ALA4433228 | cell-based format | Scientific Literature | |
| 11. | ALA4434006 | B | Agonist activity at TLR2 in mouse dendritic cells assessed as upregulation CD80 expression at 100 ng/ml by flow cytometry | Mus musculus | 4 | ALA4433228 | cell-based format | Scientific Literature | |
| 12. | ALA4434007 | B | Agonist activity at TLR2 in mouse dendritic cells assessed as upregulation CD86 expression at 100 ng/ml by flow cytometry | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 13. | ALA4434008 | B | Agonist activity at TLR2 in mouse dendritic cells assessed as upregulation MHC class 2 expression at 100 ng/ml by flow cytometry | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 14. | ALA4434009 | A | Effect on CD80 expression in TLR2-/- mouse dendritic cells at 100 ng/ml by flow cytometry | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 15. | ALA4434010 | A | Effect on CD86 expression in TLR2-/- mouse dendritic cells at 100 ng/ml by flow cytometry | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 16. | ALA4434011 | A | Effect on MHC class 2 expression in TLR2-/- mouse dendritic cells at 100 ng/ml by flow cytometry | Mus musculus | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 17. | ALA4434012 | B | Agonist activity at human TLR2 in PMA-differentiated THP-1 cells assessed as induction of IL-6 production at 0.5 to 2.5 uM incubated for 24 hrs by ELISA | Homo sapiens | 1 | ALA4433228 | cell-based format | Scientific Literature | |
| 18. | ALA4434013 | B | Agonist activity at TLR2/1 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR2-IGA for 2 hrs by ELISA | Homo sapiens | 6 | ALA4433228 | cell-based format | Scientific Literature | |
| 19. | ALA4434014 | B | Agonist activity at TLR2/1 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR1-IGG for 2 hrs by ELISA | Homo sapiens | 3 | ALA4433228 | cell-based format | Scientific Literature | |
| 20. | ALA4434015 | B | Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR6-IGG for 2 hrs by ELISA | Homo sapiens | 3 | ALA4433228 | cell-based format | Scientific Literature |
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