#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4308446	B	Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system at 10 uM preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay relative to control	Homo sapiens	120	ALA4304826	assay format	Scientific Literature
2.	ALA4308447	B	Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system at 1 uM preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay relative to control	Homo sapiens	120	ALA4304826	assay format	Scientific Literature
3.	ALA4308448	B	Inhibition of His-tagged recombinant human ATP-activated TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system preincubated with enzyme/ATP mixture for 20 mins followed by TK substrate-biotin addition followed by further incubation for 15 mins in presence of ATP by HTRF assay	Homo sapiens	120	ALA4304826	assay format	Scientific Literature
4.	ALA4308449	B	Inhibition of human full length TRKA expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assay	Homo sapiens	113	ALA4304826	cell-based format	Scientific Literature
5.	ALA4308450	B	Inhibition of human full length TRKB expressed in CHO cells assessed as decrease in NGF-induced Ca2+ flux by Calcium 4 dye-based FLIPR TETRA assay	Homo sapiens	114	ALA4304826	cell-based format	Scientific Literature
6.	ALA4308451	B	Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells assessed as association rate constant by single cycle kinetics analysis	Homo sapiens	2	ALA4304826	cell-based format	Scientific Literature
7.	ALA4308452	B	Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells assessed as dissociation rate constant by single cycle kinetics analysis	Homo sapiens	2	ALA4304826	cell-based format	Scientific Literature
8.	ALA4308453	B	Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells assessed as equilibrium rate constant by single cycle kinetics analysis	Homo sapiens	2	ALA4304826	cell-based format	Scientific Literature
9.	ALA4308454	B	Binding affinity to wild type human biotinylated and N-terminal DYKDDDDK-tagged TrkA kinase domain (436 to 790 residues) expressed in Sf21 cells assessed as residence time by single cycle kinetics analysis	Homo sapiens	2	ALA4304826	cell-based format	Scientific Literature
10.	ALA4308455	B	Inhibition of human inactive TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP measured every 5 minutes for 5 hrs by caliper method	Homo sapiens	2	ALA4304826	single protein format	Scientific Literature
11.	ALA4308456	B	Inhibition of human active TRKA assessed as decrease in substrate phosphorylation incubated for 2 hrs using CSKtide as substrate in presence of ATP measured every 5 minutes for 5 hrs by caliper method	Homo sapiens	2	ALA4304826	single protein format	Scientific Literature
12.	ALA4308458	B	Selectivity index, ratio of Ki for inhibition of human active TRKA to ratio of Ki for inhibition of inactive TRKA	Homo sapiens	1	ALA4304826	single protein format	Scientific Literature
13.	ALA4308459	A	Half life in Beagle dog plasma at 0.2 mg/kg, iv administered as bolus dose measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
14.	ALA4308460	A	AUClast in Beagle dog plasma at 0.2 mg/kg, iv administered as bolus dose measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
15.	ALA4308461	A	AUC (0 to infinity) in Beagle dog plasma at 0.2 mg/kg, iv administered as bolus dose measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
16.	ALA4308462	A	Volume of distribution at steady state in Beagle dog plasma at 0.2 mg/kg, iv administered as bolus dose measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
17.	ALA4308463	A	Clearance in Beagle dog plasma at 0.2 mg/kg, iv administered as bolus dose measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
18.	ALA4308464	A	Cmax in Beagle dog plasma at 3 mg/kg, po measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
19.	ALA4308465	A	Tmax in Beagle dog plasma at 3 mg/kg, po measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature
20.	ALA4308466	A	Half life in Beagle dog plasma at 3 mg/kg, po measured for 0.033 to 24 hrs post compound dose by protein precipitation based UPLC-MS/MS analysis	Canis lupus familiaris	1	ALA4304826	organism-based format	Scientific Literature