# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4430346 | B | Agonist activity at human RXR binding domain and activation domain expressed in human HCT116 cells assessed as rexinoid activity incubated for 24 hrs by luciferase reporter gene based mammalian two-hybrid assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
2. | ALA4430347 | B | Agonist activity at human RXR binding domain and activation domain expressed in human HCT116 cells assessed as rexinoid activity at 25 nM incubated for 24 hrs by luciferase reporter gene based mammalian two-hybrid assay relative to bexarotene | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
3. | ALA4430348 | B | Agonist activity at human RXR binding domain and activation domain expressed in human HCT116 cells assessed as rexinoid activity at 100 nM incubated for 24 hrs by luciferase reporter gene based mammalian two-hybrid assay relative to bexarotene | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
4. | ALA4430349 | B | Agonist activity at human RXR binding domain and activation domain expressed in human HCT116 cells assessed as rexinoid activity at 1000 nM incubated for 24 hrs by luciferase reporter gene based mammalian two-hybrid assay relative to bexarotene | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
5. | ALA4430352 | B | Agonist activity at human RXRalpha expressed in human HCT116 cells assessed as increase in RXRE-mediated transcription at 25 nM incubated for 24 hrs by RXRE luciferase reporter gene assay relative to bexarotene | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
6. | ALA4430353 | B | Agonist activity at human RXRalpha expressed in human HCT116 cells assessed as increase in RXRE-mediated transcription at 100 nM incubated for 24 hrs by RXRE luciferase reporter gene assay relative to bexarotene | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA4430354 | B | Agonist activity at human RXRalpha expressed in human HCT116 cells assessed as increase in RXRE-mediated transcription at 1000 nM incubated for 24 hrs by RXRE luciferase reporter gene assay relative to bexarotene | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
8. | ALA4430357 | A | Agonist activity at human RXRalpha/LXRalpha expressed in human HCT116 cells assessed as reduction in SREBP-mediated transcription activity at 100 nM incubated for 24 hrs by luciferase reporter gene assay relative to bexarotene | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
9. | ALA4430358 | A | Agonist activity at human RXRalpha/LXRalpha expressed in human HCT116 cells assessed as reduction in SREBP-mediated transcription activity at 100 nM incubated for 24 hrs by luciferase reporter gene assay in presence of 100 nM LXR agonist TO901317 relative to bexarotene | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
10. | ALA4430359 | U | Lipid risk index, ratio of agonist activity at human RXRalpha/LXRalpha expressed in human HCT116 cells assessed as reduction in SREBP-mediated transcription activity to agonist activity at human RXRalpha expressed in human HCT116 cells assessed as increase in RXRE-mediated transcription | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
11. | ALA4430360 | B | Agonist activity at RXR in human HepG2 cells assessed as induction of CYP3A4 expression at 100 nM incubated for 24 hrs by quantitative real-time PCR method relative to untreated control | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
12. | ALA4430361 | F | Growth inhibition of human HUT78 cells at 200 nM incubated for 72 hrs by MTS assay relative to bexarotene | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
13. | ALA4430363 | T | Mutagenicity in Saccharomyces cerevisiae D7 assessed as induction of mutagenesis by measuring forward and reverse mutations up to 0.1 mg/mL | Saccharomyces cerevisiae | 13 | assay format | Scientific Literature |