| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4387081 | ADME | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme residual activity incubated for 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 2. | ALA4387082 | ADME | Apparent permeability in wild type pig LLC-PK1 cells at 1 uM incubated for 3 hrs by texas red based LC-MS/MS analysis | Sus scrofa | 4 | ALA4385640 | cell-based format | Scientific Literature | |
| 3. | ALA4387083 | Binding | Inhibition of human PDE10A using cAMP as substrate preincubated for 30 mins followed by substrate addition and measured after 60 mins by HTRF detection assay | Homo sapiens | 25 | ALA4385640 | single protein format | Scientific Literature | |
| 4. | ALA4387084 | ADME | Ratio of efflux ratio of LLC-PK1 cells expressing human MDR1 at at 1 uM to efflux ratio of wild type LLC-PK1 cells at 1 uM | Sus scrofa | 24 | ALA4385640 | cell-based format | Scientific Literature | |
| 5. | ALA4387085 | ADME | Drug uptake in mouse brain at 0.1 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Mus musculus | 2 | ALA4385640 | organism-based format | Scientific Literature | |
| 6. | ALA4387086 | Physicochemical | Lipophilicity, logD of the compound at pH 7.4 | 2 | ALA4385640 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4387087 | Physicochemical | Solubility of the compound in pH 6.8 JP2 buffer | 1 | ALA4385640 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4387088 | ADME | Drug uptake in mouse plasma at 0.1 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Mus musculus | 2 | ALA4385640 | organism-based format | Scientific Literature | |
| 9. | ALA4387089 | ADME | Total brain to plasma partition coefficient, Kp in mouse at 0.1 mg/kg, po measured after 1 hr by LC-MS/MS analysis | Mus musculus | 2 | ALA4385640 | organism-based format | Scientific Literature | |
| 10. | ALA4387090 | ADME | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme residual activity incubated for 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 11. | ALA4387091 | ADME | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme residual activity incubated for 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 12. | ALA4387092 | ADME | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme residual activity incubated for 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 13. | ALA4387093 | ADME | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme residual activity incubated for 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 14. | ALA4387094 | ADME | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme residual activity incubated for 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 15. | ALA4387095 | ADME | Intrinsic clearance in human liver microsomes by LC-MS/MS analysis | Homo sapiens | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 16. | ALA4387096 | ADME | Intrinsic clearance in mouse liver microsomes by LC-MS/MS analysis | Mus musculus | 1 | ALA4385640 | microsome format | Scientific Literature | |
| 17. | ALA4387097 | Functional | Antipsychotic activity in ICR mouse assessed as inhibition of Phencyclidine-induced hyperlocomotion pretreated orally followed by Phencyclidine injection and measured after 60 mins | Mus musculus | 1 | ALA4385640 | organism-based format | Scientific Literature | |
| 18. | ALA4387098 | Functional | Cognition enhancement activity in ddY mouse assessed as suppression of MK-801-induced working memory deficit by measuring decrease in spontaneous alternation behavior at 0.1 to 0.3 mg/kg, po pretreated 40 mins before MK-801 dosing and measured after 20 mins by Y-maze test | Mus musculus | 1 | ALA4385640 | organism-based format | Scientific Literature | |
| 19. | ALA4387099 | ADME | Effect on mean number of arm entries in ddY mouse at 1 mg/kg, po pretreated 40 mins before MK-801 dosing and measured after 20 mins by Y-maze test | Mus musculus | 1 | ALA4385640 | organism-based format | Scientific Literature | |
| 20. | ALA4387100 | ADME | Effect on mean number of arm entries in ddY mouse at 0.03 to 0.3 mg/kg, po pretreated 40 mins before MK-801 dosing and measured after 20 mins by Y-maze test | Mus musculus | 1 | ALA4385640 | organism-based format | Scientific Literature |
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