# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4390738 | B | Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bovine insulin aggregation | Homo sapiens | 72 | ALA4390639 | assay format | Scientific Literature | |
2. | ALA4390740 | F | Cytotoxicity against human U87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4390639 | cell-based format | Scientific Literature | |
3. | ALA4390741 | F | Cytotoxicity against human A172 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4390639 | cell-based format | Scientific Literature | |
4. | ALA4390742 | F | Cytotoxicity against human NU04 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4390639 | cell-based format | Scientific Literature | |
5. | ALA4390748 | F | Inhibition of colony formation in human U87MG cells measured after 24 hrs by crystal violet staining based assay | Homo sapiens | 7 | ALA4390639 | cell-based format | Scientific Literature | |
6. | ALA4390750 | F | Cytotoxicity against human U87MG cells assessed as inhibition of cell proliferation at Homo sapiens | 23 | ALA4390639 | cell-based format | Scientific Literature | | |
7. | ALA4390751 | A | Cytotoxicity against HFF1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
8. | ALA4390752 | U | Therapeutic ratio of IC50 for HFF1 cells to IC50 for human NU04 cells | Homo sapiens | 6 | ALA4390639 | assay format | Scientific Literature | |
9. | ALA4390753 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 8 | ALA4390639 | assay format | Scientific Literature | |
10. | ALA4390760 | B | Induction of EIF2alpha phosphorylation in human U87MG cells at 20 uM measured after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
11. | ALA4390764 | F | Induction of endoplasmic reticulum stress in human U87MG cells assessed as increase in GRP78 expression at 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
12. | ALA4390765 | B | Induction of EIF2alpha phosphorylation in human A172 cells at 20 uM measured after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
13. | ALA4390769 | F | Induction of endoplasmic reticulum stress in human A172 cells assessed as increase in GRP78 expression at 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
14. | ALA4390770 | F | Antimigratory activity against human A172 cells assessed as reduction in cell migration towards wound area at 10 uM measured after 24 hrs by Giemsa staining based microscopic analysis | Homo sapiens | 5 | ALA4390639 | cell-based format | Scientific Literature | |
15. | ALA4390772 | F | Effect on PDI expression in human U87MG cells at 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
16. | ALA4390773 | F | Effect on PDI expression in human A172 cells at 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
17. | ALA4390774 | F | Antimigratory activity against human A172 cells at 30 uM measured after 4 hrs by Giemsa staining based transwell migration assay | Homo sapiens | 4 | ALA4390639 | cell-based format | Scientific Literature | |
18. | ALA4390775 | F | Antimigratory activity against human A172 cells at 10 uM measured after 4 hrs by Giemsa staining based transwell migration assay | Homo sapiens | 1 | ALA4390639 | cell-based format | Scientific Literature | |
19. | ALA4390780 | F | Effect on MMP2 expression in human U87MG cells at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
20. | ALA4390781 | F | Down regulation of MMP9 expression in human U87MG cells at 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4390639 | cell-based format | Scientific Literature |