# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4407308 | Functional | Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric affinity cooperativity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 67 | ALA4406806 | cell-based format | Scientific Literature | |
2. | ALA4407309 | Functional | Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring efficacy cooperativity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 67 | ALA4406806 | cell-based format | Scientific Literature | |
3. | ALA4407310 | Functional | Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric binding affinity in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 67 | ALA4406806 | cell-based format | Scientific Literature | |
4. | ALA4407311 | Functional | Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production by measuring allosteric index in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 67 | ALA4406806 | cell-based format | Scientific Literature | |
5. | ALA4407312 | Functional | Positive allosteric modulation of human GPR68 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 5 | ALA4406806 | cell-based format | Scientific Literature | |
6. | ALA4407338 | Functional | Positive allosteric modulation of human GPR4 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 3 | ALA4406806 | cell-based format | Scientific Literature | |
7. | ALA4407339 | Functional | Positive allosteric modulation of human GPR65 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 3 | ALA4406806 | cell-based format | Scientific Literature | |
8. | ALA4725212 | Toxicity | Incucyte cell viability with HEK293T | Homo sapiens | 1,713 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
9. | ALA4725213 | Toxicity | Incucyte cell viability with human fibroblast | Homo sapiens | 1,718 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
10. | ALA4725214 | Toxicity | Incucyte cell viability with U2OS | Homo sapiens | 1,712 | ALA4689842 | cell-based format | EUbOPEN Chemogenomic Library | |
11. | ALA4880023 | Binding | GPCRScan assay: inhibition of 5-HT1A | Homo sapiens | 180 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
12. | ALA4880024 | Binding | GPCRScan assay: inhibition of 5-HT1B | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
13. | ALA4880025 | Binding | GPCRScan assay: inhibition of 5-HT1D | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
14. | ALA4880026 | Binding | GPCRScan assay: inhibition of 5-HT1E | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
15. | ALA4880027 | Binding | GPCRScan assay: inhibition of 5-HT2A | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
16. | ALA4880028 | Binding | GPCRScan assay: inhibition of 5-HT2B | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
17. | ALA4880029 | Binding | GPCRScan assay: inhibition of 5-HT2C | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
18. | ALA4880030 | Binding | GPCRScan assay: inhibition of 5-HT3 | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
19. | ALA4880031 | Binding | GPCRScan assay: inhibition of 5-HT5A | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt | |
20. | ALA4880032 | Binding | GPCRScan assay: inhibition of 5-HT6 | Homo sapiens | 181 | ALA4507331 | single protein format | Donated Chemical Probes - SGC Frankfurt |