# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4339649 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 33 | ALA4339196 | cell-based format | Scientific Literature | |
2. | ALA4339650 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2A expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | ALA4339196 | cell-based format | Scientific Literature | |
3. | ALA4339651 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | ALA4339196 | cell-based format | Scientific Literature | |
4. | ALA4339652 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | ALA4339196 | cell-based format | Scientific Literature | |
5. | ALA4339653 | B | Displacement of [3H]Ro25-6981 from rat GluN2B receptor | Rattus norvegicus | 1 | ALA4339196 | single protein format | Scientific Literature | |
6. | ALA4339654 | P | Solubility of the compound at pH 2 | 3 | ALA4339196 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4339655 | P | Solubility of the compound at pH 7 | 3 | ALA4339196 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4728769 | B | Negative allosteric modulation of human GluN1a/GluN2B receptor expressed in CHO cells assessed as inhibition of glutamate and glycine-induced calcium flux preincubated for 5 mins followed by glutamate and glycine addition and measured after 5 mins by calcium 5 dye based FLIPR assay | Homo sapiens | 12 | ALA4725355 | cell-based format | Scientific Literature | |
9. | ALA4728770 | B | Negative allosteric modulation of human GluN1a/GluN2A receptor expressed in CHO cells assessed as inhibition of glutamate and glycine-induced calcium flux preincubated for 5 mins followed by glutamate and glycine addition and measured after 5 mins by calcium 5 dye based FLIPR assay | Homo sapiens | 2 | ALA4725355 | cell-based format | Scientific Literature | |
10. | ALA4728771 | B | Negative allosteric modulation of human GluN1a/GluN2C receptor expressed in CHO cells assessed as inhibition of glutamate and glycine-induced calcium flux preincubated for 5 mins followed by glutamate and glycine addition and measured after 5 mins by calcium 5 dye based FLIPR assay | Homo sapiens | 2 | ALA4725355 | cell-based format | Scientific Literature | |
11. | ALA4728772 | B | Negative allosteric modulation of human GluN1a/GluN2D receptor expressed in CHO cells assessed as inhibition of glutamate and glycine-induced calcium flux preincubated for 5 mins followed by glutamate and glycine addition and measured after 5 mins by calcium 5 dye based FLIPR assay | Homo sapiens | 2 | ALA4725355 | cell-based format | Scientific Literature | |
12. | ALA4728773 | P | Solubility of compound in phosphate buffer at pH 2 measured after 3 days | 10 | ALA4725355 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4728774 | P | Solubility of compound in phosphate buffer at pH 7 measured after 3 days | 10 | ALA4725355 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4728775 | A | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in MDCK-MDR1 cells at 5 uM measured after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 12 | ALA4725355 | cell-based format | Scientific Literature | |
15. | ALA4728776 | A | Protein binding in human plasma at 1 uM after 6 hrs by equilibrium dialysis method | Homo sapiens | 2 | ALA4725355 | cell-free format | Scientific Literature | |
16. | ALA4728777 | B | Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch method | Homo sapiens | 14 | ALA4725355 | cell-based format | Scientific Literature |