# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4381855 | B | Antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 15 | ALA4376895 | cell-based format | Scientific Literature | |
2. | ALA4381856 | B | Antagonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Mus musculus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
3. | ALA4381857 | B | Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
4. | ALA4381858 | B | Antagonist activity at rat alpha6alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
5. | ALA4381859 | B | Antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
6. | ALA4381860 | B | Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
7. | ALA4381861 | B | Antagonist activity at rat alpha2beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
8. | ALA4381862 | B | Antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 nM at -70 mV holding potential preincubated for 5 mins followed by compound washout by two electrode voltage-clamp assay | Rattus norvegicus | 2 | ALA4376895 | cell-based format | Scientific Literature | |
9. | ALA4381863 | B | Antagonist activity at rat alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response up to 10 uM at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 12 | ALA4376895 | cell-based format | Scientific Literature | |
10. | ALA4381864 | B | Antagonist activity at rat alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response up to 10 uM at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 12 | ALA4376895 | cell-based format | Scientific Literature | |
11. | ALA4381865 | B | Antagonist activity at rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response up to 10 uM at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 12 | ALA4376895 | cell-based format | Scientific Literature | |
12. | ALA4381867 | B | Selectivity ratio of IC50 for antagonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | 14 | ALA4376895 | cell-based format | Scientific Literature | ||
13. | ALA4381868 | B | Selectivity ratio of IC50 for antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
14. | ALA4381869 | B | Selectivity ratio of IC50 for antagonist activity at rat alpha6alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
15. | ALA4381870 | B | Selectivity ratio of IC50 for antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
16. | ALA4381871 | B | Selectivity ratio of IC50 for antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
17. | ALA4381872 | B | Selectivity ratio of IC50 for antagonist activity at rat alpha2beta2 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
18. | ALA4381873 | B | Antagonist activity at rat alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at >10 uM at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA4376895 | cell-based format | Scientific Literature | |
19. | ALA4381874 | B | Antagonist activity at rat alpha4beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at >10 uM at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA4376895 | cell-based format | Scientific Literature | |
20. | ALA4381875 | B | Antagonist activity at rat alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at >10 uM at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 1 | ALA4376895 | cell-based format | Scientific Literature |