# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4419373 | Binding | Inhibition of C-terminal 6x-histidine tagged beta-catenin (138 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 /human BCL9 (350 to 375 residues) protein-protein interactions incubated for 1 hr by Alpha-screen assay | Homo sapiens | 57 | ALA4419168 | assay format | Patent Bioactivity Data | |
2. | ALA4419374 | Binding | Inhibition of C-terminal 6x-histidine tagged beta-catenin (138 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 DE3/N-terminally biotinylated human E-cadherin (824 to 877 residues) protein-protein interactions by Alpha-screen assay | Homo sapiens | 10 | ALA4419168 | assay format | Patent Bioactivity Data | |
3. | ALA4419375 | Binding | Selectivity index, ratio of Ki for inhibition of C-terminal 6x-histidine tagged beta-catenin (138 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 DE3/N-terminally biotinylated human E-cadherin (824 to 877 residues) protein-protein interactions by Alpha-screen assay to Ki for Inhibition of C-terminal 6x-histidine tagged beta-catenin (138 to 686 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 /human BCL9 (350 to 375 residues) protein-protein interactions incubated for 1 hr by Alpha-screen assay | Homo sapiens | 10 | ALA4419168 | assay format | Patent Bioactivity Data | |
4. | ALA4419380 | Binding | Inhibition of inhibited beta-catenin D145A mutant (unknown origin) expressed in Escherichia coli BL21 DE3 /human BCL9 (350 to 375 residues) protein-protein interactions by Alpha-screen assay | Homo sapiens | 3 | ALA4419168 | assay format | Patent Bioactivity Data | |
5. | ALA4419381 | Binding | Inhibition of inhibited beta-catenin E155A mutant (unknown origin) expressed in Escherichia coli BL21 DE3 /human BCL9 (350 to 375 residues) protein-protein interactions by Alpha-screen assay | Homo sapiens | 3 | ALA4419168 | assay format | Patent Bioactivity Data | |
6. | ALA4419382 | Binding | Inhibition of inhibited beta-catenin D145A/E155A mutant (unknown origin) expressed in Escherichia coli BL21 DE3 /human BCL9 (350 to 375 residues) protein-protein interactions by Alpha-screen assay | Homo sapiens | 3 | ALA4419168 | assay format | Patent Bioactivity Data | |
7. | ALA4419401 | Binding | Inhibition of beta-catenin/BCL9 (unknown origin) expressed in Wnt-activated HEK293 cells assessed as reduction in canonical Wnt signaling transactivation by Wnt-responsive luciferase reporter assay | Homo sapiens | 2 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
8. | ALA4419402 | Binding | Inhibition of beta-catenin/BCL9 in Wnt-activated human SW480 cells assessed as reduction in canonical Wnt signaling transactivation by Wnt-responsive luciferase reporter assay | Homo sapiens | 3 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
9. | ALA4419403 | Binding | Inhibition of beta-catenin/BCL9 in Wnt-activated human MDA-MB-231 cells assessed as reduction in canonical Wnt signaling transactivation by Wnt-responsive luciferase reporter assay | Homo sapiens | 2 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
10. | ALA4419416 | Functional | Cytotoxicity in human SW480 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 3 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
11. | ALA4419417 | Functional | Cytotoxicity in human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 3 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
12. | ALA4419419 | Functional | Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 47 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
13. | ALA4419420 | Functional | Cytotoxicity in human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 2 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
14. | ALA4419421 | Functional | Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 2 | ALA4419168 | cell-based format | Patent Bioactivity Data | |
15. | ALA4419422 | ADME | Cytotoxicity in human MCF10A cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay | Homo sapiens | 2 | ALA4419168 | cell-based format | Patent Bioactivity Data |