# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4381855 | Binding | Antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 15 | ALA4376895 | cell-based format | Scientific Literature | |
2. | ALA4381856 | Binding | Antagonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Mus musculus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
3. | ALA4381857 | Binding | Antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
4. | ALA4381858 | Binding | Antagonist activity at rat alpha6alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
5. | ALA4381859 | Binding | Antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
6. | ALA4381860 | Binding | Antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
7. | ALA4381861 | Binding | Antagonist activity at rat alpha2beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
8. | ALA4381862 | Binding | Antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 10 nM at -70 mV holding potential preincubated for 5 mins followed by compound washout by two electrode voltage-clamp assay | Rattus norvegicus | 2 | ALA4376895 | cell-based format | Scientific Literature | |
9. | ALA4381866 | Binding | Antagonist activity at rat alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Rattus norvegicus | 2 | ALA4376895 | cell-based format | Scientific Literature | |
10. | ALA4381867 | Binding | Selectivity ratio of IC50 for antagonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | 14 | ALA4376895 | cell-based format | Scientific Literature | ||
11. | ALA4381868 | Binding | Selectivity ratio of IC50 for antagonist activity at rat alpha7 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
12. | ALA4381869 | Binding | Selectivity ratio of IC50 for antagonist activity at rat alpha6alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
13. | ALA4381870 | Binding | Selectivity ratio of IC50 for antagonist activity at rat alpha3beta2 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
14. | ALA4381871 | Binding | Selectivity ratio of IC50 for antagonist activity at rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
15. | ALA4381872 | Binding | Selectivity ratio of IC50 for antagonist activity at rat alpha2beta2 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | Rattus norvegicus | 14 | ALA4376895 | cell-based format | Scientific Literature | |
16. | ALA4381876 | Binding | Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -70 mV holding potential by two electrode voltage-clamp assay | Homo sapiens | 2 | ALA4376895 | cell-based format | Scientific Literature | |
17. | ALA4381877 | Binding | Selectivity ratio of IC50 for antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes to IC50 for antagonist activity at rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes | 1 | ALA4376895 | cell-based format | Scientific Literature | ||
18. | ALA4381878 | Binding | Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 50 nM at -70 mV holding potential by two electrode voltage-clamp assay relative to control | Homo sapiens | 2 | ALA4376895 | cell-based format | Scientific Literature | |
19. | ALA4381879 | Binding | Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 100 nM at -70 mV holding potential by two electrode voltage-clamp assay relative to control | Homo sapiens | 2 | ALA4376895 | cell-based format | Scientific Literature |