# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4404752 | B | Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues) expressed in Escherichia coli BL21 (DE3) cells using 0.4 uM acetyl coenzyme A and N-terminal histone H4 peptide (sequence SGRGKGGKGLGKGGAKRHRKV-GGK-biotin) as substrate incubated for 60 mins by Alpha screen technology | Homo sapiens | 177 | cell-based format | Scientific Literature | ||
2. | ALA4404753 | B | Inhibition of recombinant KAT6A (unknown origin) expressed in C57BL/6 mouse embryonic fibroblasts assessed as reduction in cell proliferation supplemented with fresh medium containing compounds every 48 hrs after for 168 hrs under low oxygen condition | Homo sapiens | 9 | assay format | Scientific Literature | ||
3. | ALA4404755 | A | Protein binding in mouse plasma at 1000 ng/mL after 4.2 hrs by LC-MS analysis based ultracentrifugation assay | Mus musculus | 11 | cell-free format | Scientific Literature | ||
4. | ALA4404757 | P | Kinetic solubility of the compound in 0.01 M HCl at pH 2 by nephelometry | 16 | small-molecule physicochemical format | Scientific Literature | |||
5. | ALA4404758 | P | Kinetic solubility of the compound in phosphate buffer at pH 6.5 by nephelometry | 16 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4404759 | A | Half-life in mouse liver microsomes at 1 uM measured over 60 mins in presence of NADPH-regenerating system by UPLC/MS analysis | Mus musculus | 14 | microsome format | Scientific Literature | ||
7. | ALA4404760 | A | Half-life in human liver microsomes at 1 uM measured over 60 mins in presence of NADPH-regenerating system by UPLC/MS analysis | Homo sapiens | 15 | microsome format | Scientific Literature | ||
8. | ALA4404761 | A | Intrinsic clearance in mouse liver microsomes assessed per mg protein at 1 uM measured over 60 mins in presence of NADPH-regenerating system by UPLC/MS analysis | Mus musculus | 15 | microsome format | Scientific Literature | ||
9. | ALA4404762 | A | Intrinsic clearance in human liver microsomes assessed per mg protein at 1 uM measured over 60 mins in presence of NADPH-regenerating system by UPLC/MS analysis | Homo sapiens | 15 | microsome format | Scientific Literature | ||
10. | ALA4404765 | A | Apparent permeability across apical to basolateral side in human Caco2 cells measured over 90 mins by LC-MS/MS analysis | Homo sapiens | 11 | cell-based format | Scientific Literature |