# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4393241 | B | Inhibition of recombinant human Cav3.1 expressed in HEK293 cells assessed as reduction in KCl-induced increase in intracellular calcium level at 10 uM by fura-2 AM indicator based FDSS assay relative to control | Homo sapiens | 16 | ALA4392842 | cell-based format | Scientific Literature | |
2. | ALA4393242 | B | Inhibition of Cav3.2 (unknown origin) assessed as reduction in KCl-induced increase in intracellular calcium level at 10 uM by fura-2 AM indicator based FDSS assay relative to control | Homo sapiens | 16 | ALA4392842 | cell-based format | Scientific Literature | |
3. | ALA4393243 | A | Stability in human liver microsomes assessed as parent compound remaining measured after 30 mins | Homo sapiens | 16 | ALA4392842 | microsome format | Scientific Literature | |
4. | ALA4393244 | B | Inhibition of human ERG by whole-cell patch clamp method | Homo sapiens | 16 | ALA4392842 | assay format | Scientific Literature | |
5. | ALA4393245 | B | Inhibition of recombinant human Cav3.1 expressed in HEK293 cells assessed as suppression of KCl-evoked current by whole-cell patch clamp method | Homo sapiens | 1 | ALA4392842 | cell-based format | Scientific Literature | |
6. | ALA4393246 | B | Inhibition of Cav3.2 (unknown origin) assessed as suppression of KCl-evoked current by whole-cell patch clamp method | Homo sapiens | 1 | ALA4392842 | assay format | Scientific Literature | |
7. | ALA4393247 | A | Inhibition of CYP2C19 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4392842 | single protein format | Scientific Literature | |
8. | ALA4393248 | A | Inhibition of CYP1A2 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4392842 | single protein format | Scientific Literature | |
9. | ALA4393249 | A | Inhibition of CYP2D6 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4392842 | single protein format | Scientific Literature | |
10. | ALA4393250 | A | Inhibition of CYP2C9 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4392842 | single protein format | Scientific Literature | |
11. | ALA4393251 | A | Inhibition of CYP3A4 (unknown origin) assessed as residual activity at 10 uM relative to control | Homo sapiens | 1 | ALA4392842 | single protein format | Scientific Literature | |
12. | ALA4393252 | F | Analgesic activity in Sprague-Dawley rat L5/L6 spinal nerve ligation-induced neuropathic pain model assessed as reversal of mechanical allodynia by measuring increase in paw withdrawal threshold to non-noxious mechanical stimuli at 100 mg/kg, po measured after 3 hrs relative to control | Rattus norvegicus | 2 | ALA4392842 | organism-based format | Scientific Literature | |
13. | ALA4393253 | F | Analgesic activity in Sprague-Dawley rat L5/L6 spinal nerve ligation-induced neuropathic pain model assessed as decrease in paw withdrawal threshold to non-noxious cold stimuli at 100 mg/kg, po measured after 1 hr | Rattus norvegicus | 1 | ALA4392842 | organism-based format | Scientific Literature | |
14. | ALA4393254 | F | Analgesic activity in Sprague-Dawley rat L5/L6 spinal nerve ligation-induced neuropathic pain model assessed as decrease in paw withdrawal threshold to non-noxious cold stimuli at 100 mg/kg, po measured after 5 hrs | Rattus norvegicus | 2 | ALA4392842 | organism-based format | Scientific Literature |