#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4305534	Binding	Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide22 substrate phosphorylation incubated for 90 mins	Homo sapiens	21	ALA4304751	assay format	Scientific Literature
2.	ALA4305535	Binding	Inhibition of myc/His-tagged ETV6-FER (452 to 821 residues) (unknown origin) expressed in BA/F3 cells assessed as decrease in cell viability after 3 days by luminescence based CellTiter-Glo assay	Homo sapiens	8	ALA4304751	cell-based format	Scientific Literature
3.	ALA4305536	ADME	Growth inhibition of mouse mock transfected BA/F3 cells assessed as decrease in cell viability after 3 days by luminescence based CellTiter-Glo assay	Mus musculus	6	ALA4304751	cell-based format	Scientific Literature
4.	ALA4305537	ADME	Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 1 uM after 30 mins relative to control	Mus musculus	2	ALA4304751	microsome format	Scientific Literature
5.	ALA4305538	Physicochemical	Solubility in buffer at pH 6.8		2	ALA4304751	small-molecule physicochemical format	Scientific Literature
6.	ALA4305539	ADME	Protein binding in BALB/c mouse serum at 10 ug/mL incubated for 4 hrs under shaking condition by LC/MS/MS analysis	Mus musculus	2	ALA4304751	cell-free format	Scientific Literature
7.	ALA4305540	ADME	Effective permeability of compound at 5 uM after 24 hrs at pH 7.4 by LC/MS/MS based PAMPA assay		2	ALA4304751	assay format	Scientific Literature
8.	ALA4305541	ADME	Total plasma clearance in BALB/cAnNCrlCrlj mouse at 1 mg/kg, iv after 24 hrs	Mus musculus	2	ALA4304751	organism-based format	Scientific Literature
9.	ALA4305542	ADME	AUC in BALB/cAnNCrlCrlj mouse at 10 mg/kg, po administered via gavage after 24 hrs	Mus musculus	2	ALA4304751	organism-based format	Scientific Literature
10.	ALA4305543	ADME	Cmax in BALB/cAnNCrlCrlj mouse at 10 mg/kg, po administered via gavage after 24 hrs	Mus musculus	2	ALA4304751	organism-based format	Scientific Literature
11.	ALA4305544	ADME	Oral bioavailability in BALB/cAnNCrlCrlj mouse at 10 mg/kg administered via gavage after 24 hrs	Mus musculus	2	ALA4304751	organism-based format	Scientific Literature
12.	ALA4305545	Functional	Antitumor activity against mouse BA/F3 cells expressing myc/His-tagged ETV6-FER kinase domain (452 to 821 residues) allografted in BALB/cAJcl nu/nu mouse assessed as decrease in tumor volume administered orally once per day for 4 days starting from 6 days after tumor cell implantation and measured during compound dosing	Mus musculus	1	ALA4304751	cell-based format	Scientific Literature
13.	ALA4305546	Toxicity	Toxicity in BALB/cAJcl nu/nu mouse allografted with mouse BA/F3 cells expressing myc/His-tagged ETV6-FER kinase domain (452 to 821 residues) assessed as change in body weight loss at 12.5 to 100 mg/kg, po administered once per day for 4 days starting from 6 days after tumor cell implantation and measured during compound dosing	Mus musculus	1	ALA4304751	organism-based format	Scientific Literature
14.	ALA4305547	ADME	Unbound plasma concentration in BALB/cAnNCrlCrlj mouse at 10 mg/kg, po administered via gavage after 24 hrs by non-compartmental analysis	Mus musculus	1	ALA4304751	organism-based format	Scientific Literature
15.	ALA4305548	Binding	Inhibition of recombinant N-terminal GST-fusion protein tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system assessed as decrease in fluorescence labelled Srctide phosphorylation at 200 nM by off-chip mobility shift assay relative to control	Homo sapiens	1	ALA4304751	assay format	Scientific Literature
16.	ALA4305549	Binding	Inhibition of recombinant N-terminal GST-fusion protein tagged human FLT3 cytoplasmic domain (564 to 993 residues) expressed in baculovirus expression system assessed as decrease in fluorescence labelled Srctide phosphorylation at 200 nM by off-chip mobility shift assay relative to control	Homo sapiens	1	ALA4304751	assay format	Scientific Literature
17.	ALA4305550	Binding	Inhibition of recombinant N-terminal GST-fusion protein tagged human FMS cytoplasmic domain (538 to 972 residues) expressed in baculovirus expression system assessed as decrease in fluorescence labelled Srctide phosphorylation at 200 nM by off-chip mobility shift assay relative to control	Homo sapiens	1	ALA4304751	assay format	Scientific Literature
18.	ALA4305551	Binding	Inhibition of recombinant N-terminal GST-fusion protein tagged human KIT cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system assessed as decrease in fluorescence labelled Srctide phosphorylation at 200 nM by off-chip mobility shift assay relative to control	Homo sapiens	1	ALA4304751	assay format	Scientific Literature
19.	ALA4305552	Binding	Inhibition of recombinant N-terminal GST-fusion protein tagged human full length PYK2 (1 to 967 residues) expressed in baculovirus expression system assessed as decrease in fluorescence labelled Blk/Lyntide phosphorylation at 200 nM by off-chip mobility shift assay relative to control	Homo sapiens	1	ALA4304751	assay format	Scientific Literature
20.	ALA4305553	Binding	Inhibition of recombinant N-terminal GST-fusion protein tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in baculovirus expression system assessed as decrease in fluorescence labelled IRS1 phosphorylation at 200 nM by off-chip mobility shift assay relative to control	Homo sapiens	1	ALA4304751	assay format	Scientific Literature